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Major Depressive Disorder

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December 02, 2021
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Sage Therapeutics, Biogen highlight data showing zuranolone well-tolerated in MDD

Sage Therapeutics Inc. and Biogen Inc. released 12-month data showing zuranolone was generally well-tolerated among adults with major depressive disorder.

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November 17, 2021
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Lithium may not reduce suicide-related events in veterans with mood disorders

Lithium may not reduce suicide-related events in veterans with mood disorders

Adding lithium to usual care for veterans with major depression or bipolar disorders did not reduce incidence of suicide-related events, according to results of a randomized clinical trial published in JAMA Psychiatry.

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November 01, 2021
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Social determinants of health adversely affect outcomes in severe mental illness

Patients with severe mental illness, particularly those with schizophrenia who are insured by Medicaid, have significant social risk factors that may adversely affect overall health, according to a study presented at Psych Congress.

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October 19, 2021
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Functioning worsens in patients with bipolar, MDD only during depressive episodes

A longitudinal study assessing illness progression in patients with bipolar disorder and major depressive disorder found a worsening of patient function with depressive episodes, but an overall improvement in functioning over 5 years.

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October 04, 2021
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Caplyta reduces bipolar disorder-associated depressive episodes

Caplyta reduced depression symptoms in patients with major depressive episodes linked to bipolar I and bipolar II disorders, according to a phase 3 randomized placebo-controlled trial in American Journal of Psychiatry.

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October 01, 2021
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Insulin resistance measures may predict incident major depressive disorder

Insulin resistance measures may predict incident major depressive disorder

Surrogate insulin resistance measures positively predicted incident major depressive disorder among adults with no depression or anxiety disorder history, according to a study in American Journal of Psychiatry.

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September 16, 2021
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Ketamine monotherapy reduces suicidal ideation in adults with depression

In adults with treatment-resistant depression, ketamine monotherapy significantly reduced suicidal ideation compared with adjunctive ketamine, according to a retrospective study in Journal of Psychiatric Research.

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September 13, 2021
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Major depressive episode persistence, severity differ by race/ethnicity

Major depressive episode persistence, severity differ by race/ethnicity

Researchers have identified racial and ethnic disparities in major depressive episode persistence and severity, according to study results in a research letter published in JAMA Psychiatry.

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August 12, 2021
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Suicidal behaviors common in U.S. veterans, yet most receive no mental health care

Suicidal behaviors common in U.S. veterans, yet most receive no mental health care

Study results published in Journal of Clinical Psychiatry indicated that suicidal behaviors were common among U.S. veterans, especially among young veterans.

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August 11, 2021
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Increasing sample sizes in genetic studies may help better estimate risk for depression

Increasing sample sizes in genetic studies may help better estimate risk for depression

Increasing sample sizes in genetic studies, regardless of the depth of phenotyping, may help better estimate risk for depression, according to results of a case-control polygenic risk score analysis published in JAMA Psychiatry.

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