Major Depressive Disorder

Sage Therapeutics Inc. and Biogen Inc. released 12-month data showing zuranolone was generally well-tolerated among adults with major depressive disorder.

Adding lithium to usual care for veterans with major depression or bipolar disorders did not reduce incidence of suicide-related events, according to results of a randomized clinical trial published in JAMA Psychiatry.

Patients with severe mental illness, particularly those with schizophrenia who are insured by Medicaid, have significant social risk factors that may adversely affect overall health, according to a study presented at Psych Congress.

A longitudinal study assessing illness progression in patients with bipolar disorder and major depressive disorder found a worsening of patient function with depressive episodes, but an overall improvement in functioning over 5 years.

Caplyta reduced depression symptoms in patients with major depressive episodes linked to bipolar I and bipolar II disorders, according to a phase 3 randomized placebo-controlled trial in American Journal of Psychiatry.

Surrogate insulin resistance measures positively predicted incident major depressive disorder among adults with no depression or anxiety disorder history, according to a study in American Journal of Psychiatry.

In adults with treatment-resistant depression, ketamine monotherapy significantly reduced suicidal ideation compared with adjunctive ketamine, according to a retrospective study in Journal of Psychiatric Research.

Researchers have identified racial and ethnic disparities in major depressive episode persistence and severity, according to study results in a research letter published in JAMA Psychiatry.

Study results published in Journal of Clinical Psychiatry indicated that suicidal behaviors were common among U.S. veterans, especially among young veterans.

Increasing sample sizes in genetic studies, regardless of the depth of phenotyping, may help better estimate risk for depression, according to results of a case-control polygenic risk score analysis published in JAMA Psychiatry.