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Major Depressive Disorder

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December 07, 2022
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Ulotaront enters phase 2/3 clinical trial for MDD treatment efficacy

Ulotaront enters phase 2/3 clinical trial for MDD treatment efficacy

Two pharmaceutical firms announced they have started a phase 2/3 trial to evaluate the efficacy of ulotaront, a trace amine-associated receptor 1 agonist, as an adjunctive therapy for major depressive disorder treatment, according to a joint press release.

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December 02, 2022
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FDA issues ‘study may proceed’ letter for clinical trial for MDD treatment

FDA issues ‘study may proceed’ letter for clinical trial for MDD treatment

The FDA has issued a “study may proceed” letter to biopharmaceutical company Vistagen for its newly filed investigational new drug application for the clinical development of PH10, a treatment for major depressive disorder.

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November 30, 2022
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Phase 2 trial initiated for depression treatment targeting specific biomarker

Phase 2 trial initiated for depression treatment targeting specific biomarker

EmbarkNeuro, a neuroscience biotech company formerly known as Ancora Bio, announced its phase 2 trial is under way for ANC-501, a first-in-class vasopressin 1b receptor antagonist for the treatment of major depressive disorder.

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November 11, 2022
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Psilocybin improves treatment-resistant depression, but linked to adverse events

Psilocybin improves treatment-resistant depression, but linked to adverse events

A 25 mg dose of psilocybin was associated with improvements in treatment-resistant depression over a 3-week period, but with adverse events, a recent study found.

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October 19, 2022
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Depression treatment shows ‘robust efficacy’ in women in phase 2 trial

Depression treatment shows ‘robust efficacy’ in women in phase 2 trial

Arrivo BioVentures, a biopharmaceutical company, has announced preliminary results from a randomized, placebo-controlled phase 2 clinical trial of SP-624, a first-in-class, sirtuin 6 activator for the treatment of major depressive disorder.

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October 17, 2022
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D-cycloserine enhances TMS treatment for depression

D-cycloserine enhances TMS treatment for depression

NMDA-receptor partial agonist D-cycloserine enhanced transcranial magnetic stimulation treatment outcomes in those with major depressive disorder, researchers reported.

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October 17, 2022
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No link between subclinical hypothyroidism, major depressive disorder among adolescents

No link between subclinical hypothyroidism, major depressive disorder among adolescents

Adolescents with subclinical hypothyroidism do not have an increased risk for major depressive disorder compared with those with normal thyroid function, according to a study published in Thyroid.

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September 23, 2022
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Treatment significantly improved symptoms in those with MDD, childhood trauma

Treatment significantly improved symptoms in those with MDD, childhood trauma

In individuals with major depressive disorder and childhood trauma, symptoms improved significantly following pharmacological and psychotherapeutic treatments, regardless of severity, per a study published in Lancet Psychiatry.

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September 09, 2022
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FDA grants breakthrough designation for device to treat MDD in adults

FDA grants breakthrough  designation for device to treat MDD in adults

The FDA has granted breakthrough device designation to Magnus Medical for its neuromodulation treatment of major depressive disorder in adults who failed to achieve improvement from previously prescribed antidepressants.

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August 29, 2022
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Starting ECT earlier to treat MDD, bipolar disorder may improve clinical outcomes

Starting ECT earlier to treat MDD, bipolar disorder may improve clinical outcomes

Introducing electroconvulsive therapy earlier in a treatment course for major depressive disorder or bipolar disorder may lead to improvements in clinical outcomes, according to a study published in the Journal of Clinical Psychiatry.

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