Lupus
Models to predict lupus based on genetics, lifestyle perform ‘very well in all situations’
WASHINGTON — A model predicting the development of systemic lupus erythematosus, based on genetic, lifestyle and environmental factors, was successfully validated in a large cohort, according to data presented at ACR Convergence 2024.
Herpes zoster vaccine effective, shows ‘no signs’ of increased severe flare risk in lupus
WASHINGTON — Herpes zoster vaccination is effective in patients with systemic lupus erythematosus and multiple sclerosis, without increasing the risk for severe lupus flares, according to data presented at ACR Convergence 2024.
Black children with lupus have higher disease activity, less likely to achieve low activity
Black and multiracial children with systemic lupus erythematosus demonstrate higher disease activity and are less likely to achieve low disease activity compared with white children, according to data published in Arthritis Care & Research.
Highest, lowest vitamin D levels predict adverse pregnancy outcomes in lupus
Among pregnant women with systemic lupus erythematosus, those who demonstrate either high or low levels of serum vitamin D are more likely to experience miscarriage, preterm delivery and other adverse outcomes, according to data.
FDA clears way for trial of novel bispecific T-cell engager for lupus
The FDA has cleared an investigational new drug application allowing a novel bispecific T-cell engager to begin a phase 1 trial in patients with active, moderate-to-severe systemic lupus erythematosus, according to a press release.
Placenta lesions common in lupus pregnancies with small for gestational age infants
Among pregnancies in patients with systemic lupus erythematosus, those with small for gestational age infants were significantly more likely to demonstrate increased perivillous fibrin deposition in the placenta, according to data.
Repeat kidney biopsies may help manage lupus nephritis flares
Repeat kidney biopsies may help patients with lupus nephritis manage disease flares, particularly those who transition between proliferative and non-proliferative disease classes, data from a racially diverse study cohort show.
Advanced MRI finds brain abnormalities linked to cognitive dysfunction in lupus
Advanced structural MRI can detect brain abnormalities linked with cognitive dysfunction in patients with systemic lupus erythematosus, according to a systematic review published in Lupus Science & Medicine.
Newly illuminated molecular roots of lupus may lead to treatments with ‘durable benefits’
A recent investigation into the molecular roots of systemic lupus erythematosus may point the way toward a new generation of therapeutic targets, according to the researchers.
Zetomipzomib trial in lupus nephritis paused after four patient deaths
Kezar Life Sciences has paused a phase 2b trial of zetomipzomib in active lupus nephritis after reporting four patient deaths, according to a press release from the manufacturer.