Lung Function
Race-neutral lung function equations alter FEV1, FVC in pediatric patients with asthma
SAN DIEGO — Following use of race-neutral lung function equations, African American and Latino pediatric patients with asthma had reductions in FEV1 and FVC while white patients with asthma had increases, according to a presentation here.
Admilparant slows lung function decline in IPF, progressive PF
Receiving admilparant, an oral lysophosphatidic acid receptor 1 antagonist, for 26 weeks lowered percent-predicted FVC decline in idiopathic and progressive pulmonary fibrosis, according to study results.
Individuals with impaired FEV1/FVC trajectories often experience wheeze before middle age
Around 20% to 25% of individuals with rapidly declining FEV1/FVC trajectories experienced wheezing and usual phlegm/bronchitis as adolescents/young adults, according to results published in The Lancet Respiratory Medicine.
Positive topline data reported in phase 3 trial of nerandomilast in progressive PF
Adults with progressive pulmonary fibrosis met the primary endpoint of absolute change in FVC with 52-week oral nerandomilast, an investigational phosphodiesterase 4B inhibitor, vs. placebo, according to FIBRONEER-ILD topline results.
Genetic risk score plus lung function questionnaire improves COPD prediction
The ability to predict spirometry-defined COPD was significantly better when a modified lung function questionnaire score was used in combination with a COPD polygenic risk score, according to results published in JAMA.
FDA grants brensocatib priority review for bronchiectasis
The FDA has granted priority review to brensocatib to treat patients with non-cystic fibrosis bronchiectasis, according to a manufacturer-issued press release.
Immunotherapy platform for ALS slows disease progression, extends survival
A new analysis of an overall survival study of an investigational immunotherapy platform to treat ALS found it slowed disease progression and extended survival, according to the manufacturer.
Patients with COPD, preserved ratio impaired spirometry have faster frailty progression
Frailty progression occurred at a faster rate among patients with COPD and preserved ratio impaired spirometry vs. those with normal spirometry, according to results published in CHEST.
Children’s lung function improved with classroom, bedroom air purification
In a set of healthy school-aged children, several lung function measures, including FEV1 and FVC, improved with classroom plus bedroom air purification, according to results published in JAMA Pediatrics.
Deupirfenidone reduces FVC decline, well tolerated in IPF at 26 weeks
Patients with idiopathic pulmonary fibrosis had less FVC decline between baseline and 26 weeks with receipt of three daily doses of 825 mg deupirfenidone, according to phase 2b ELEVATE IPF trial results.