Liver Injury

The FDA granted orphan drug designation for KB408 for the treatment of alpha-1 antitrypsin deficiency, according to a press release from Krystal Biotech.

Receiving an mRNA or inactivated COVID-19 vaccine did not increase the risk for acute liver injury, according to a study published in Journal of Hepatology.

In a Healio video exclusive, Harvey Kaufman, MD, senior medical director at Quest Diagnostics, highlighted the need for concurrent hepatitis B and latent tuberculosis testing to mitigate the risk for drug-induced liver injury.

Two doses of icosabutate were well tolerated and safe in patients with nonalcoholic steatohepatitis.

Mitochondrial mechanisms of toxicity may be an important cause of drug-induced liver injury, according to a study published in Acta Pharmaceutica Sinica B.

For patients with severe COVID-19, cholangiopathy was a late complication with potential for progressive biliary injury or liver failure, according to a study published in the American Journal of Gastroenterology.

Chronic hepatitis B virus, whether current or past, was not associated with increased incidence of acute liver injury or death among patients with COVID-19, according to research presented at the International Liver Congress.

Patients with drug-indued liver injury had a long hospital stay, low morbidity and high mortality, according to a study published in the British Journal of Clinical Pharmacology.

The ACG developed recommendations for diagnosis and management of idiosyncratic drug-induced liver injury.

The incidence of abnormal liver enzymes among transgender men and women prescribed gender-affirming hormone therapy is low, with no cases of symptomatic liver injury observed after 1 year of treatment, data show.