Levothyroxine
‘Spectrum of risk’ exists for papillary thyroid carcinoma

Aggressive papillary thyroid carcinoma variants appeared associated with a wide range of survival outcomes, suggesting greater emphasis should be placed on tailored treatment approaches for patients with histologically and prognostically distinct subtypes, according to study results published in JAMA Oncology.
Bedtime vs. breakfast levothyroxine administration may boost free thyroxine level
UK NICE guideline favors levothyroxine, radioactive iodine therapy for thyroid disorders

Physicians who treat patients with hypothyroidism should opt for levothyroxine monotherapy in most patients, and when treating patients with Graves’ disease, radioactive iodine is the optimal treatment option, according to a summary of new National Institute for Health and Care Excellence, or NICE, guidelines published in The BMJ.
Hypothyroidism, HT exert opposite risks for postmenopausal breast cancer

In a large prospective cohort of postmenopausal women, those who had ever had hypothyroidism — whether treated with levothyroxine or not — were less likely to develop breast cancer than those without hypothyroidism, and the relationship was more pronounced among those who did not also use menopausal hormone therapy, according to findings published in Thyroid.