Leukemia
Blinatumomab shows benefit in pediatric B-cell ALL in first relapse
Results of two studies published in JAMA showed the addition of blinatumomab to consolidation chemotherapy improved outcomes for children and young adults with high-risk first relapse of B-cell acute lymphoblastic leukemia.
Registry aims to improve understanding of how COVID-19 affects patients with blood cancer
The Leukemia & Lymphoma Society launched a national patient registry designed to improve understanding of how the novel coronavirus and COVID-19 vaccination affect people with blood cancer.
Should therapy for hematologic malignancies be modified to mitigate poor COVID-19 outcomes?
COVID-19 infections in patients with hematologic malignancies tend to have a much worse prognosis, with mortality rates twice as high as those of patients without hematologic malignancies. These rates are currently up to 34% overall among adults and up to 47% among those aged older than 60 years. Underlying immunosuppression related to the malignancy itself and further potentiated by the therapy likely contributes to high mortality seen among these patients.
COVID-19 and blood cancer: Evolving science on a dangerous comorbidity
More than a year into the COVID-19 pandemic, new information emerges daily about the virus and its effects on various vulnerable populations.
Despite challenges, CAR-T may have ‘expanded role’ for children
Chimeric antigen receptor T-cell therapy has been heralded as a transformative addition to the cancer treatment armamentarium.
Relapse after CAR-T liked to shorter survival among younger patients with ALL
Younger patients who experienced disease progression after CD19-directed chimeric antigen receptor T-cell therapy had significantly shorter OS than those who did not relapse, according to results presented at TCT Meetings Digital Experience.
PARP inhibitors may increase risk for myelodysplastic syndrome, AML
Poly(ADP-ribose) polymerase, or PARP, inhibitors appeared associated with increased risk for secondary myelodysplastic syndrome and acute myeloid leukemia compared with placebo among patients with cancer, according to study results.
Total body irradiation regimen superior to chemotherapy conditioning in pediatric ALL
Total body irradiation plus etoposide improved OS and appeared to reduce risk for relapse among children with high-risk acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplant, study results showed.
Celebrating Black Pioneers of Medicine
The Association for the Study of African American Life and History instituted an annual celebration and recognition of Black history in 1926.
Anti-CD22 CAR T-cell therapy a ‘promising option’ for advanced B-cell malignancies
An investigational chimeric antigen receptor T-cell therapy appeared safe and demonstrated antitumor activity among patients with relapsed or refractory B-cell malignancies, according to results presented at TCT Meetings Digital Experience.