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Leukemia

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April 13, 2022
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New mutations may have implications for BTK inhibitor use in chronic lymphocytic leukemia

New mutations may have implications for BTK inhibitor use in chronic lymphocytic leukemia

Justin Taylor, MD, spoke with Healio about a study he and colleagues conducted to examine mechanisms of resistance to noncovalent Bruton tyrosine kinase inhibitors.

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April 12, 2022
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Certain genetic patterns may predict response to CAR-T for acute lymphoblastic leukemia

Certain genetic patterns may predict response to CAR-T for acute lymphoblastic leukemia

Younger patients with acute lymphoblastic leukemia who do not respond to CD19-directed chimeric antigen receptor T-cell therapy exhibit certain gene regulation patterns that may be associated with treatment resistance, study results show.

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April 12, 2022
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New COVID-19 vaccine may protect patients with B-cell deficiencies

New COVID-19 vaccine may protect patients with B-cell deficiencies

CoVac-1, a COVID-19 vaccine, induced T-cell responses in patients with B-cell deficiencies, including those with lymphoma and leukemia, according to study results presented during American Association for Cancer Research Annual Meeting.

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April 05, 2022
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FDA grants fast track designation to CD33-directed CAR-T for acute myeloid leukemia

FDA grants fast track designation to CD33-directed CAR-T for acute myeloid leukemia

The FDA granted fast track designation to PRGN-3006 for the treatment of adults with relapsed or refractory acute myeloid leukemia.

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March 25, 2022
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Next breakthrough for CAR T cells may come in acute myeloid leukemia

Next breakthrough for CAR T cells may come in acute myeloid leukemia

Commercially available chimeric antigen receptor T cells for acute myeloid leukemia could be just a few years away, according to a presenter at the inaugural Personalizing Pediatric Cancer Care Summit.

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March 23, 2022
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Investigational therapy for B-cell malignancies offers three targets in one CAR T cell

Investigational therapy for B-cell malignancies offers three targets in one CAR T cell

B-cell activating factor is a ligand protein, which makes it uniquely suited as a therapeutic option for the newly emerging class of multitargeted chimeric antigen receptor T-cell therapies.

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March 18, 2022
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FDA grants orphan drug status to CAR-T for T-cell acute lymphoblastic leukemia

FDA grants orphan drug status to CAR-T for T-cell acute lymphoblastic leukemia

The FDA granted orphan drug designation to WU-CART-007 for patients with relapsed or refractory T-cell acute lymphoblastic leukemia.

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March 18, 2022
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FDA grants orphan drug designation to OmnImmune cell therapy for acute myeloid leukemia

FDA grants orphan drug designation to OmnImmune cell therapy for acute myeloid leukemia

The FDA granted orphan drug designation to TCB-002 for treatment of adults with relapsed or refractory acute myeloid leukemia.

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March 10, 2022
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FDA grants orphan drug designation to CRISPR-edited cell therapy for AML

FDA grants orphan drug designation to CRISPR-edited cell therapy for AML

The FDA granted orphan drug designation to NTLA-5001 for treatment of adults with relapsed or refractory acute myeloid leukemia.

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March 07, 2022
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FDA grants priority review to ivosidenib for certain patients with acute myeloid leukemia

FDA grants priority review to ivosidenib for certain patients with acute myeloid leukemia

The FDA granted priority review to ivosidenib tablets in combination with azacitidine for previously untreated IDH1-mutated acute myeloid leukemia.

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