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June 14, 2022
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Bortezomib extends survival of children with newly diagnosed T-cell lymphoblastic lymphoma

Bortezomib extends survival of children with newly diagnosed T-cell lymphoblastic lymphoma

The addition of bortezomib to chemotherapy significantly improved survival outcomes among children and young adults with T-cell lymphoblastic lymphoma, according to phase 3 study results published in Journal of Clinical Oncology.

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June 14, 2022
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Pathogenic germline variants identified in adults with acute myeloid leukemia

Pathogenic germline variants identified in adults with acute myeloid leukemia

Approximately 14% of adults with acute myeloid leukemia harbored germline pathogenic or likely pathogenic variants in a hematologic malignancy predisposition gene, according to study results published in Blood.

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June 12, 2022
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Intramuscular recombinant Erwinia asparaginase active, safe in leukemia, lymphoma subsets

Intramuscular recombinant <i>Erwinia</i> asparaginase active, safe in leukemia, lymphoma subsets

A phase 2/phase 3 study assessed intramuscular asparaginase Erwinia chrysanthemi (recombinant)-rywn for patients with acute lymphoblastic leukemia or lymphoblastic lymphoma who developed hypersensitivity to E. coli-derived L-asparaginase.

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June 09, 2022
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Asciminib safer, more effective than bosutinib in chronic-phase chronic myeloid leukemia

Asciminib safer, more effective than bosutinib in chronic-phase chronic myeloid leukemia

CHICAGO — Asciminib continued to confer superior efficacy and better safety and tolerability than bosutinib among patients with chronic-phase chronic myeloid leukemia, according to study results presented during ASCO Annual Meeting.

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June 06, 2022
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Daratumumab improves response among younger patients with acute lymphoblastic leukemia

Daratumumab improves response among younger patients with acute lymphoblastic leukemia

CHICAGO — The addition of daratumumab to chemotherapy improved outcomes among younger patients with relapsed or refractory T-cell acute lymphoblastic leukemia, study results showed.

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June 01, 2022
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FDA grants fast track designation to mocravimod with HSCT for acute myeloid leukemia

FDA grants fast track designation to mocravimod with HSCT for acute myeloid leukemia

The FDA granted fast track designation to mocravimod in combination with allogeneic hematopoietic stem cell transplantation for post-remission therapy of acute myeloid leukemia.

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May 26, 2022
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FDA approves ivosidenib plus azacitidine for certain patients with acute myeloid leukemia

FDA approves ivosidenib plus azacitidine for certain patients with acute myeloid leukemia

The FDA approved ivosidenib tablets in combination with azacitidine for previously untreated IDH1-mutated acute myeloid leukemia.

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May 25, 2022
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Hypomethylating therapy may activate, upregulate oncogene

Hypomethylating therapy may activate, upregulate oncogene

Treatment with a hypomethylating agent may activate or upregulate SALL4, an oncogene that plays a key role in myelodysplastic syndrome and other cancers, according to study results published in The New England Journal of Medicine.

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May 24, 2022
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World Trade Center responders have higher burden of mutations linked to blood cancers

World Trade Center responders have higher burden of mutations linked to blood cancers

First responders to the World Trade Center had higher rates of clonal hematopoiesis-associated mutations than firefighters not exposed to the dust, gases and potential carcinogens at the site, according to a study in Nature Medicine.

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May 23, 2022
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FDA approves azacitidine for pediatric leukemia indication

FDA approves azacitidine for pediatric leukemia indication

The FDA approved azacitidine for treatment of pediatric patients with newly diagnosed juvenile myelomonocytic leukemia.

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