Leiden University Medical Center
Pre-arthritis methotrexate use improves RA course, fails to prevent clinical arthritis
Methotrexate use at the pre-arthritis stage of symptoms and subclinical inflammation fails to prevent clinical arthritis, but does improve symptoms and MRI-detected inflammation vs. placebo, according to data published in The Lancet.
Most women who take anticoagulants for blood clots experience abnormal menstrual bleeding
Two-thirds of women of child-bearing age who began taking anticoagulants for acute venous thromboembolism had abnormally heavy menstrual bleeding in the months that followed therapy initiation, according to data from a prospective study.
Upadacitinib efficacious in patients with ankylosing spondylitis refractory to biologics
Upadacitinib is efficacious over 14 weeks in patients with ankylosing spondylitis who mounted poor responses to biologic disease-modifying antirheumatic drugs, according to data published in the Annals of the Rheumatic Diseases.
Novel approaches highlight potential of cell therapy for a wider array of cancers
The ideal strategy to treat cancer with cell therapy can vary greatly depending on tumor type.
Unvalidated patient-reported outcome measures limit acromegaly, GH studies
One-third of acromegaly and growth hormone deficiency studies report discrepancies between patient-reported outcomes and biochemical outcomes, with many using unvalidated and poorly reported outcome measures, data from a meta-analysis show.
Oral baricitinib maintains lower radiographic progression than csDMARD, placebo in RA
Oral baricitinib is linked to lower levels of 5-year radiographic progression than first-line conventional, synthetic disease-modifying antirheumatic drugs or placebo in rheumatoid arthritis, according to data published in The Journal of Rheumatology.
Perimenstrual migraine attack duration affects recurrence risk, triptan use
Longer duration of perimenstrual migraine attacks among women with menstrual-related migraine appeared linked to increased recurrence risk and triptan use, according to results of a prospective study published in Neurology.
No association found between subclinical thyroid dysfunction and cognitive decline
Subclinical hypothyroidism and hyperthyroidism are not associated with cognitive function, cognitive decline or dementia, according to an analysis of data of more than 74,000 people from 23 cohorts published in JAMA Internal Medicine.
Physical therapy referrals for systemic sclerosis underused in primary care
There is a “large variability” in the use of physical therapy for systemic sclerosis, and patients who do receive it are rarely treated for hand or oral dysfunction, according to data published in Arthritis Care & Research.
Ixekizumab demonstrates low radiographic progression in axial SpA at 2 years
Most patients with active, radiographic axial spondyloarthritis who receive ixekizumab for 2 years show no radiographic disease progression, with low mean progression overall, according to a poster presentation at the EULAR 2021 Congress.