Left Ventricular Hypertrophy

The introduction of mavacamten represents a major shift in the treatment of obstructive hypertrophic cardiomyopathy, but raises dosing and drug-drug interaction challenges.

Among adults with apparent resistant hypertension, treatment with renal denervation improved left ventricular hypertrophy and LV ejection fraction but had no significant effect on diastolic function, according to a new meta-analysis.

In a proof-of-concept phase 2 trial, a novel SK ion channel inhibitor successfully converted atrial fibrillation to sinus rhythm compared with placebo.

Researchers have developed the first prediction model for the prediction of HF- and arrhythmia-related major adverse cardiac events in patients with mitochondrial diseases.

Researchers reported that serum sodium above 143 mmol/L at middle age, an indicator of hypohydration, was associated with risk for HF and left ventricular hypertrophy many years later.

Hypertrophic cardiomyopathy is the most common genetic heart disease, with prevalence estimates from one in 200 to one in 500. However, the true prevalence is poorly understood due to likely underdiagnosis.

The rate of diabetes is nearly three times higher in American Indians and Alaska Natives compared with white Americans, which increases their risk for CVD, according to an American Heart Association scientific statement.

Malignant left ventricular hypertrophy, a subtype in which patients have elevations in cardiac biomarkers associated with risk for HF, is more common in black individuals compared with white individuals and may partly help explain racial disparities in HF, researchers reported.

Weight gain and increased systolic BP in collegiate U.S. football players may be due to concentric left ventricular hypertrophy, arterial stiffening and reduced left ventricular diastolic function, according to a study published in JAMA Cardiology.