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Janus Kinase Inhibitor

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October 17, 2023
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Opzelura effective, well tolerated in children aged at least 2 years with atopic dermatitis

Opzelura effective, well tolerated in children aged at least 2 years with atopic dermatitis

Opzelura achieved significant efficacy for the treatment of atopic dermatitis in children aged as young as 2 years, Incyte announced in a press release.

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September 12, 2023
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‘The elephant in the room’: Age, disease-related factors may drive JAK safety signals

‘The elephant in the room’: Age, disease-related factors may drive JAK safety signals

SAN DIEGO — Patient age and disease-related factors may be driving safety signals in medications used to treat rheumatoid arthritis and psoriatic disease, according to a speaker at the 2023 Congress of Clinical Rheumatology West.

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September 08, 2023
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Head-to-head trial data in rheumatoid arthritis scant, offer ‘shaky evidence’

Head-to-head trial data in rheumatoid arthritis scant, offer ‘shaky evidence’

SAN DIEGO — Rheumatology research still offers too few head-to-head clinical trials of biologic medications to help clinicians manage rheumatoid arthritis, according to data presented at the 2023 Congress of Clinical Rheumatology West.

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August 22, 2023
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Colectomies ‘infrequent’ in patients with moderate to severe UC receiving tofacitinib

Colectomies ‘infrequent’ in patients with moderate to severe UC receiving tofacitinib

All patients with moderate to severe ulcerative colitis in the tofacitinib OCTAVE UC clinical program who underwent colectomy had prior tumor necrosis factor inhibitor failure and most had additional risk factors, according to analysis.

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August 09, 2023
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‘Lipid paradox’ may obscure cardiovascular risk in patients with inflammatory disease

‘Lipid paradox’ may obscure cardiovascular risk in patients with inflammatory disease

AUSTIN, Texas — Providers should carefully consider the “lipid paradox” when monitoring cardiovascular risks in patients with rheumatic inflammatory diseases, noted a presenter at the 2023 Rheumatology Nurses Society annual conference.

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July 26, 2023
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First patient dosed in global phase 3 trial of Rinvoq for hidradenitis suppurativa

First patient dosed in global phase 3 trial of Rinvoq for hidradenitis suppurativa

Researchers have dosed the first patient in Step-Up HS, a phase 3 study evaluating Rinvoq for moderate to severe hidradenitis suppurativa in adults and adolescents, AbbVie announced in a press release.

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July 13, 2023
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Brepocitinib superior to placebo in reducing psoriatic arthritis signs, symptoms

Brepocitinib superior to placebo in reducing psoriatic arthritis signs, symptoms

Brepocitinib, in doses of either 30 mg or 60 mg, is superior to placebo in reducing signs and symptoms of psoriatic arthritis and is “generally well tolerated” through 52 weeks, according to data published in Arthritis & Rheumatology.

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July 11, 2023
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VIDEO: Praise for oral, topical JAK inhibitors for atopic dermatitis

VIDEO: Praise for oral, topical JAK inhibitors for atopic dermatitis

In this Healio video exclusive, George Martin, MD, discusses highlights from Maui Derm NP+PA, including the use of oral and topical JAK inhibitors to treat atopic dermatitis.

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July 11, 2023
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VIDEO: Highlights in psoriasis from Maui Derm NP+PA

VIDEO: Highlights in psoriasis from Maui Derm NP+PA

In this video, George Martin, MD, discusses highlights in the treatment of psoriasis

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July 04, 2023
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VIDEO: Interesting developments in the psoriatic arthritis pipeline

VIDEO: Interesting developments in the psoriatic arthritis pipeline

M. Elaine Husni, MD, MPH, spoke with Healio about treatment and management options in psoriatic arthritis, including lifestyle changes. “We now have really embraced the concept of wellness strategies,” said Husni, vice chair of rheumatology and director of the Arthritis and Musculoskeletal Center and staff physician in the Orthopedic and Rheumatologic Institute at Cleveland Clinic, and assistant professor at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

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