Janus Kinase Inhibitor

All patients with moderate to severe ulcerative colitis in the tofacitinib OCTAVE UC clinical program who underwent colectomy had prior tumor necrosis factor inhibitor failure and most had additional risk factors, according to analysis.

AUSTIN, Texas — Providers should carefully consider the “lipid paradox” when monitoring cardiovascular risks in patients with rheumatic inflammatory diseases, noted a presenter at the 2023 Rheumatology Nurses Society annual conference.

Researchers have dosed the first patient in Step-Up HS, a phase 3 study evaluating Rinvoq for moderate to severe hidradenitis suppurativa in adults and adolescents, AbbVie announced in a press release.

Brepocitinib, in doses of either 30 mg or 60 mg, is superior to placebo in reducing signs and symptoms of psoriatic arthritis and is “generally well tolerated” through 52 weeks, according to data published in Arthritis & Rheumatology.

In this Healio video exclusive, George Martin, MD, discusses highlights from Maui Derm NP+PA, including the use of oral and topical JAK inhibitors to treat atopic dermatitis.

In this video, George Martin, MD, discusses highlights in the treatment of psoriasis

M. Elaine Husni, MD, MPH, spoke with Healio about treatment and management options in psoriatic arthritis, including lifestyle changes. “We now have really embraced the concept of wellness strategies,” said Husni, vice chair of rheumatology and director of the Arthritis and Musculoskeletal Center and staff physician in the Orthopedic and Rheumatologic Institute at Cleveland Clinic, and assistant professor at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University.

In this video, John M. Davis, III, MD, clinical rheumatologist and professor of medicine at Mayo Clinic College of Medicine and Science, discusses the role of JAK inhibitors in rheumatoid arthritis treatment, and growing understanding of their effects.

Based on the pathogenesis of eosinophilic cellulitis, treatment targeting Janus kinase 1 and 2 should be developed to treat this disease, according to a study.