Iron

CHICAGO — In the IRONMAN trial, long-term IV iron supplementation in patients with HF and iron deficiency was safe and reduced risk for recurrent HF hospitalizations and CV death compared with usual care.

Outcomes among adults without anemia with and without iron deficiency presenting for elective cardiac surgery.

Among adults without anemia presenting for elective cardiac surgery, iron deficiency was not associated with fewer days alive and at home when assessed at postoperative day 30 or 90, researchers reported in The Lancet Haematology.

Different definitions of iron deficiency provide discordant results for prevalence and prognosis of chronic HF, according to research published in the Journal of the American College of Cardiology.

Among patients undergoing maintenance hemodialysis, high-dose IV iron reduced the rate of fatal or nonfatal MIs over 2 years compared with lower-dose iron, according to an analysis of the PIVOTAL trial published in Cardiovascular Research.

Among middle-aged individuals in Europe, absolute and functional iron deficiency were associated with incident CHD, and functional iron deficiency was linked to elevated risk for mortality, researchers reported.

Less frequent, higher doses of iron supplementation for patients on hemodialysis did not meet noninferiority standards for maintaining hemoglobin levels compared with the traditional treatment of more frequent doses, according to a study.

The British Society of Gastroenterology published guidelines for the management of iron deficiency anemia among an adult population.

Jay B. Wish, MD, professor of clinical medicine at Indiana University School of Medicine and co-chair of the Nephrology News & Issues Editorial Advisory Board, talked about a subanalysis presented at ASN Kidney Week on roxadustat.

In clinical trials, patients with nondialysis-dependent chronic kidney disease using the hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat saw an increase in hemoglobin levels regardless of their iron status, according to an abstract presented at the virtual National Kidney Foundation Spring Clinical Meetings.