Insulin Resistance

A cohort of Canadian adults prescribed statins, and hydrophilic statins, in particular, had higher levels of insulin resistance compared with non-statin users, according to findings published in the Journal of the Endocrine Society.

Levels of anti-Müllerian hormone and the soluble anti-Müllerian hormone receptor 2 could indicate the severity of glucose metabolism impairment associated with remaining ovarian function among women with polycystic ovary syndrome.

Cardiologists should collaborate with obstetricians, gynecologists and primary care physicians to properly identify and treat women with CVD, according to a primer published in Circulation.

Adults with high levels of serum ferritin may be more likely to develop type 2 diabetes than those with lower levels, whereas those with a greater soluble transferrin receptor-to-ferritin ratio may be less likely to develop the condition, according to findings published in the Journal of Diabetes Investigation.

Adults with type 2 diabetes who undergo surgery need more insulin following surgery, particularly if they experience increased C-reactive protein level or HbA1c, according to findings published in the Journal of Diabetes Investigation.

The response to a glucose-potentiated arginine test varied between those with and without obesity among a cohort of adults with type 2 diabetes, particularly in insulin sensitivity and proinsulin secretory ratio, which suggests that beta-cell function is “compromised” in patients without obesity, according to findings published in Diabetes/Metabolism Research and Reviews.

Sustained blood sugar elevations were linked to an increased risk for cognitive decline in older adults, according to results of a population-based study published in Journal of the American Geriatrics Society. Researchers also found that the hormone adiponectin was likely a risk factor for cognitive decline in older adults without abdominal obesity.

Women treated with the overactive bladder medication mirabegron experienced rises in brown adipose tissue metabolic activity as well as insulin sensitivity, resting energy expenditure and other metabolic factors after 4 weeks of treatment, according to findings published in the Journal of Clinical Investigation.

Men with elevated apolipoprotein A-I levels may be less likely to develop type 2 diabetes, and those with a certain polymorphism may be the best candidates for the prediction of the disease’s development via homeostasis model assessment of insulin resistance and the avoidance of the condition via exercise, according to findings published in Nutrition, Metabolism & Cardiovascular Diseases.

Lipid oxidation rate — an indicator of “metabolic flexibility” — may be greater among women with normal weight vs. women with overweight or obesity during pregnancy, according to findings published in Metabolism. In addition, insulin resistance and inflammation may be influenced by this flexibility.