Inflammatory Cascade

Satralizumab may be an effective option to reduce the frequency of relapse in patients with neuromyelitis optica spectrum disorder, an autoimmune disease leading to inflammatory demyelinating lesions of the spinal cord and optic nerves. Analyses of the phase 3 SAkuraSky and SAkuraStar studies seem promising, according to one presenter at the virtual Association for Research in Vision and Ophthalmology meeting.

Patients with chronic kidney disease who were assigned recombinant human C1 esterase inhibitor, or rhC1INH, before coronary angiography had a lower risk for renal injury compared with those assigned placebo, with a favorable safety profile, especially in those with multiple comorbidities, according to findings from the PROTECT study published in JACC: Cardiovascular Interventions.