Immune-Mediated Inflammatory Diseases

Pregnant patients with lupus or antiphospholipid syndrome have a higher risk for preterm birth, although immune-mediated inflammatory diseases in general are “only weakly associated” with adverse pregnancy outcomes, according to data.

VYNE Therapeutics has announced its second-quarter 2023 financial results as well as business updates for its two novel investigative drugs, according to a press release.

Patients with immune-mediated inflammatory diseases demonstrate a lower, less durable COVID-19 vaccine response and are at risk for losing humoral immune protection, according to data published in The Lancet Rheumatology.

Patients with immune-mediated inflammatory diseases receiving B-cell depleting therapies are at risk for COVID-19 regardless of vaccine status, but outpatient use of monoclonal antibodies improves clinical outcomes, according to data.

CLEVELAND — Cassandra Calabrese, DO, emphasized the importance of vaccines for patients with immune-mediated inflammatory diseases at the Medical Dermatology Therapy Update II meeting.

Scientific advancement has yielded slow but steady progress in the understanding of COVID-19, particularly in patients with immune-mediated conditions, a presenter said at the Basic and Clinical Immunology for the Busy Clinician symposium.

Dermatologists should be prepared to discuss COVID-19 vaccines with their patients who have immune-mediated inflammatory diseases and how biologic treatments may be affected, according to a review.

Although the seroprevalence of SARS-CoV-2 in patients with immune-mediated inflammatory diseases is comparable to the general population, increased systemic inflammation among these patients is linked to symptomatic COVID-19, according to researchers.

Data revealed “substantial” medication changes among patients with rheumatoid arthritis amid the pandemic, with 30% reporting a medication change during the first 3 months. It was the top story in rheumatology last week.

Janus kinase inhibitors “may prove useful” in a wider range of immune-mediated inflammatory diseases, including refractory cutaneous dermatomyositis, chronic plaque psoriasis and other conditions, according to a speaker here.