Immune Checkpoint Inhibitor

The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis has updated its 2015 treatment recommendations of psoriatic arthritis to include the most up-to-date information.

Immune checkpoint inhibitor therapy appeared associated with an increased risk for major adverse cardiovascular events among patients with cancer and a prior history of cardiovascular disease, according to results of a retrospective study.

Although they exhibit a greater risk for severe immune-related adverse effects, patients with preexisting autoimmune disease receiving immune checkpoint inhibitors for melanoma had better 2-year survival than controls, according to data.

Researchers at New York University, Weill Cornell Medicine and New York Genome Center have developed and tested a two-step approach that uses whole-exome sequencing to find genes and pathways that predict response to immunotherapy.

CHICAGO — Cabozantinib plus atezolizumab showed encouraging clinical activity in patients with inoperable locally advanced or metastatic urothelial carcinoma, according to data from the COSMIC-021 study.

In this video, Melina Marmarelis, MD, discussed results from two FDA pooled analyses in lung cancer that were presented at the ASCO annual meeting.

Obesity appeared associated with improved immunotherapy outcomes among patients with certain cancer types, according to a cohort study published in JAMA Network Open.

CHICAGO —Adding relatlimab to nivolumab improved PFS, OS and objective response rates across key subgroups of patients with previously untreated metastatic or unresectable melanoma, according to a study presented at ASCO Annual Meeting.

CHICAGO — A sequential schedule of fixed-dose pembrolizumab with chemoradiotherapy conferred numerically higher PFS rates vs. concurrent timing of the drug among patients with locally advanced head and neck cancer, study results showed.

Patients with cancer undergoing treatment with immune checkpoint inhibitors did not experience exacerbations in their asthma, according to a study published in Annals of Allergy, Asthma & Immunology.