Hypothyroidism

A cohort of adults with schizophrenia in Israel had a higher rate of hypothyroidism after diagnosis than controls without schizophrenia, although no difference was found before diagnosis between the two groups, according to study data.

Acella Pharmaceuticals is voluntarily recalling one lot of 15 mg and one lot of 120 mg levothyroxine and liothyronine tablets due to subpotency, according to an FDA announcement.

Among patients with subclinical hypothyroidism and acute MI, treatment with levothyroxine demonstrated no significant improvement in left ventricular function compared with placebo, researchers reported.

Physiologic variations in thyroid-stimulating hormone concentrations may lead to a misclassification of subclinical thyroid disease for some healthy pregnant women, possibly subjecting women to unnecessary treatment, researchers report.

Results of a large study showed that 10% of patients with diabetes who were hospitalized with COVID-19 died and 20.3% required intubation within 7 days of admission. It was the top story story in endocrinology last week.

In May, Healio readers were interested in sex hormones being investigated for treating COVID-19, greater COVID-19 complications for patients with diabetes and obesity, associations between thyroid dysfunction and working hours, and more.

Hypothyroidism was more than 2.5 times more prevalent among Korean adults who worked between 53 and 83 hours per week than those who worked between 36 and 42 hours per week.

Women with obesity and primary hypothyroidism prescribed levothyroxine continued to have a lower resting energy expenditure, a measurement of whole-body metabolism, when compared with similar women who were euthyroid, according to findings published in The Journal of Clinical Endocrinology & Metabolism.

Adults with hypothyroidism taking levothyroxine therapy may derive a greater benefit when taking the drug at bedtime vs. before breakfast, according to findings published in Clinical Endocrinology.

Physicians who treat patients with hypothyroidism should opt for levothyroxine monotherapy in most patients, and when treating patients with Graves’ disease, radioactive iodine is the optimal treatment option, according to a summary of new National Institute for Health and Care Excellence, or NICE, guidelines published in The BMJ.