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Hypothalamic Obesity

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April 07, 2025
2 min read
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Setmelanotide leads to significant decrease in BMI for patients with hypothalamic obesity

A group of children and adults with hypothalamic obesity receiving setmelanotide for 1 year had nearly a 20% greater BMI reduction than those receiving placebo, according to top-line results released by Rhythm Pharmaceuticals.

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June 26, 2024
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Top in endocrinology: Setmelanotide reduces BMI; dangers of endocrine-disrupting chemicals

Results of a phase 2 trial showed that 89% of children and adults with hypothalamic obesity had a 5% or greater reduction in BMI after receiving setmelanotide over 16 weeks.

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June 18, 2024
3 min read
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Setmelanotide lowers BMI by 5% or more for most people with hypothalamic obesity

Setmelanotide reduced BMI by at least 5% at 16 weeks among 89% of children and adults with hypothalamic obesity, according to findings from a phase 2 trial published in The Lancet Diabetes & Endocrinology.

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November 04, 2022
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Significant weight loss among patients with hypothalamic obesity seen with setmelanotide

SAN DIEGO — Treatment with the melanocortin-4 receptor agonist setmelanotide was associated with significant weight loss among patients with hypothalamic obesity, according to a presenter at ObesityWeek.

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November 02, 2022
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FDA grants breakthrough therapy designation to setmelanotide for hypothalamic obesity

The FDA has granted breakthrough therapy designation to setmelanotide for patients with hypothalamic obesity, according to a company press release.

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July 26, 2021
1 min read
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FDA grants orphan drug designation for hypothalamic obesity treatment

The FDA granted orphan drug designation for an investigational combination therapy for the treatment of hypothalamic obesity, according to an industry press release.