Hypercholesterolemia

Despite guidelines recommending periodic laboratory testing in patients with HIV on ART, it may be beneficial to delay liver, renal and lipid testing in low-risk patients to minimize exposure to COVID-19, new data suggest.

Evinacumab, a novel fully human monoclonal antibody against angiopoietin-like 3, reduced LDL by more than 50% compared with placebo in patients with refractory hypercholesterolemia, researchers reported.

The number of adults with severe hypercholesterolemia prescribed general and high-intensity statins in a Kentucky health system falls below recommended guidelines, according to a study published in The American Journal of Cardiology.

Children with heterozygous familial hypercholesterolemia who received monthly injections of evolocumab had greater reductions in LDL and other lipid variables at 24 weeks compared with placebo, according to results of the HAUSER-RCT trial.

Bempedoic acid with maximally tolerated statins safely decreased LDL compared with placebo among patients with hypercholesterolemia, researchers found.

LDL reduction with alirocumab (Praluent, Sanofi/Regeneron) every 2 weeks vs. placebo in patients with homozygous familial hypercholesterolemia.

Cardiologists should collaborate with obstetricians, gynecologists and primary care physicians to properly identify and treat women with CVD, according to a primer published in Circulation.

Managing CVD and risks for cardiac conditions before, during and after pregnancy is essential to improve outcomes for both mother and baby, according to an American Heart Association scientific statement published in Circulation.

Three machine learning approaches outperformed the Dutch Lipid Score to diagnose patients with genetic mutations that cause familial hypercholesterolemia, according to a study published in the European Journal of Preventive Cardiology.

Two studies presented at the virtual American College of Cardiology Scientific Session highlight new options for LDL cholesterol reduction in patients with homozygous familial hypercholesterolemia.