Headache

An integrated ambulatory care model that had infusion capacity for pediatric refractory headache appeared feasible and beneficial for these patients, according to a quality improvement study.

Healio Neurology’s most-viewed stories from 2021 highlight developments surrounding Aduhelm, the benefits of flavonoid on cognitive function and neurologic symptoms in COVID-19.

Reyvow, Nurtec ODT and Ubrelvy were less efficacious than triptans for treating migraines, but these new pharmacologic agents correlated with fewer adverse events, according to a study published in JAMA Network Open.

The likelihood that opioid treatment for common neurological conditions was initiated appeared to decrease with greater access to neurologists or other specialists who offered alternative pain treatment.

Mindfulness-based stress reduction appeared to safely treat total migraine burden with long-lasting effects, according to findings presented at the annual meeting of the American Neurological Association.

Oral atogepant once per day effectively decreased the number of migraine and headache days over 12 weeks, according to findings from the phase 3 ADVANCE trial that were published in The New England Journal of Medicine.

Cefaly Technology’s nerve stimulation device, when compared with sham stimulation, was more effective in delivering pain relief and freedom from most bothersome migraine symptom, phase 3 trial data show.

Nitrates were the most frequent cause of medication-induced headaches, according to an analysis of more than 2.6 million records in the FDA’s Adverse Event Reporting System.

Pediatric patients with headache experienced increased headache frequency, poorer anxiety and mood, less physical activity and more screen time during the COVID-19 pandemic, despite reported improvements in hydration, sleep and diet.

Researchers observed no statistically significant differences between Ajovy and placebo for the treatment of posttraumatic headache among adults enrolled in a phase 2 study that evaluated the safety and efficacy of Ajovy.