Hdl Cholesterol

PHILADELPHIA — HDL cholesterol has not been shown to have a causal role in atherosclerotic cardiovascular disease, nor has lowering it reduced CV outcomes, but it may serve as a marker for CVD risk, according to a speaker.

Improving HDL function may improve outcomes after acute MI for patients with multivessel disease and high LDL, according to a subanalysis of the AEGIS II trial presented at the National Lipid Association Scientific Sessions.

ATLANTA — Monthly administration of subcutaneous olezarsen substantially reduced triglyceride levels compared with placebo among patients with predominantly moderate hypertriglyceridemia and elevated CV risk, according to new phase 2 data.

ATLANTA — Four weekly infusions of a novel formulation of human apolipoprotein A-I did not reduce a combination of CV endpoints at 90 days for adults with acute MI, multivessel disease and additional CV risk factors, researchers reported.

Elevated lipid levels were associated with worsening structural and functional cardiac damage in adolescents and young adults, though in the case of LDL, the relationship was partially mediated by elevated BP and fat mass, data show.

DALLAS — In this Healio video exclusive, Michael S. Irwig, MD, discusses how gender-confirming hormone therapy may affect obesity and cardiometabolic health.

Older adults with high levels or low levels of HDL had a small increased risk for dementia compared with those with average levels, researchers reported in Neurology.

Postmenopausal women with high total or HDL cholesterol have an increased risk for heart failure compared with women with normal cholesterol levels, according to a study published in Menopause.