Graft Survival

PHILADELPHIA — Preemptive kidney transplant in older adults with a high kidney donor profile index pre-transplant may be linked to better patient and graft survival, data show.

CareDx Inc. has partnered with Miromatrix Medical Inc. to address the organ supply shortage and improve transplantation outcomes by researching the use of bioengineered organs in humans, according to the press release.

A data-driven algorithm, RejectClass, may provide a “holistic and quantitative” measurement of kidney transplant injury phenotypes and severity, according to investigators.

Compared with the Kaplan-Meier estimator, researchers found multi-state models provided a more accurate and comprehensive assessment of the life course and graft risk of older kidney transplant recipients.

The 5-year allograft survival of a kidney transplanted from a deceased donor infected with the hepatitis C virus is comparable to a kidney from a donor who is not infected, according to data published in JAMA Network.

Compared with kidneys from deceased donors, organs from living donors show best graft survival in pediatric patients.

Among patients with focal segmental glomerulosclerosis, immunosuppressant therapy reduced proteinuria but showed no certain impact on kidney function.

In this video, Philippe Gauthier, MD, a transplant nephrologist and senior medical director of organ health at Natera, discusses a two-threshold algorithm that uses donor-derived cell-free DNA and quantity to detect transplant rejection.

Kidney transplant recipients with HIV who receive kidneys from deceased donors with HIV show positive overall and allograft survival, according to a presentation at the American Transplant Congress.

Transplanting kidneys from donors who have the hepatitis C virus into patients who are HCV-negative is not associated with increased risk for early graft failure, according to a presentation at the American Transplant Congress.