Glycated Hemoglobin A

The longitudinal increase of HbA1c was found to be independently associated with elevated incidence of CV events for patients with diabetes and multivessel CAD, according to findings published in JAMA Network Open.

Using HbA1c may not alter the effectiveness of screening for cardiovascular disease risk among adults with prediabetes, although CVD risk is greater among this group vs. those with lower HbA1c levels, according to findings published in Diabetes Care.

PHILADELPHIA — Adults with type 2 diabetes and obesity without CVD experienced dramatic metabolic improvements after a 12-week, low-calorie diet intervention but saw no change in diastolic function, which was only observed with an aerobic exercise intervention, according to data presented at the American Heart Association Scientific Sessions.

Among a cohort of adults with type 2 diabetes, HbA1c and fasting plasma glucose were effectively reduced via treatment with the small-molecule glucagon receptor antagonist RVT-1502, according to findings published in Diabetes Care.

PHILADELPHIA — Women who consumed a higher proportion of their daily calories after 6 p.m. had poorer overall CV health and higher BP, BMI and HbA1c levels, researchers reported at the American Heart Association Scientific Sessions.

The Endocrinologic and Metabolic Drugs Advisory Committee of the FDA voted 14-2 against recommending approval of a supplemental new drug application for the SGLT2 inhibitor empagliflozin 2.5 mg as an oral medication adjunct to insulin therapy for adults with type 1 diabetes, with committee members citing uncertainty regarding the adjudication of diabetic ketoacidosis and a lack of adequate data to support evidence for safety and efficacy.

Oral semaglutide was shown to be superior to placebo for lowering HbA1c and body weight among adults with type 2 diabetes already taking insulin with or without metformin, according to findings published in Diabetes Care.

When assessing glycemic management in diabetes, measuring glycated albumin may be a more effective tool than measuring HbA1c, particularly among patients with a recent diabetes diagnosis, according to findings published in the Journal of Diabetes and its Complications.

Mortality and hospitalization risks are higher for adults with type 2 diabetes who experience larger fluctuations in HbA1c or have very high or very low average HbA1c levels, according to findings published in Diabetes Care.

Factors that may impede attendance at diabetes self-management education and support, or DSMES, sessions include lower socioeconomic status, required copayments, higher HbA1c, multiple medications and the use of insulin, according to findings published in Diabetes Educator.