Glucocorticoid

Postmenopausal women who are prescribed antidepressants, beta-blockers and insulin are more likely to experience weight gain than those who do not use these medications, according to a study published in Menopause.

Moderate to high glucocorticoid use, defined as 10 mg per day or more, is associated with a greater risk for hospitalization for COVID-19 among patients with rheumatic disease, according to data published in Annals of the Rheumatic Diseases.

Adults with congenital adrenal hyperplasia who received an oral corticotropin-releasing hormone antagonist for 14 days experienced significant reductions in androgen levels with no serious adverse events, study data show.

Ruxolitinib appeared to be more effective than common treatments for patients with glucocorticoid-refractory acute graft-versus-host-disease, according to results of a randomized phase 3 study published in The New England Journal of Medicine.

Patients with knee osteoarthritis who participated in physical therapy demonstrated less pain and functional disability at 1 year compared with those who received glucocorticoid injection, according to data published in The New England Journal of Medicine.

Adults who are prescribed glucocorticoid therapy for common conditions, such as asthma, allergies and arthritis, as well as individuals with adrenal insufficiency, are at high risk for developing serious complications from COVID-19 due to an inability to mount a normal stress response, according to an editorial published in the Journal of Clinical Endocrinology & Metabolism.

A new study published in The New England Journal of Medicine has offered further characterization of critically ill patients with COVID-19 who received treatment in the Seattle region.

Adults with inflammatory disease prescribed glucocorticoid therapy experienced an improvement in several metabolic parameters after adding metformin therapy for 12 weeks compared with similar adults assigned placebo, according to findings from a phase 2 study published in The Lancet Diabetes & Endocrinology.

Endocrine Today has compiled a list of the top recent news reports focused on neuroendocrinology and adrenal medicine.

Children and adolescents with congenital adrenal hyperplasia, or CAH, diagnosed early via a neonatal screening program and treated with hydrocortisone had normal psychometric intelligence and executive function compared with population controls, according to findings published in The Journal of Clinical Endocrinology & Metabolism.