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October 10, 2024
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Advanced MRI finds brain abnormalities linked to cognitive dysfunction in lupus

Advanced MRI finds brain abnormalities linked to cognitive dysfunction in lupus

Advanced structural MRI can detect brain abnormalities linked with cognitive dysfunction in patients with systemic lupus erythematosus, according to a systematic review published in Lupus Science & Medicine.

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September 17, 2024
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Anti-Ro antibodies in lupus portend higher disease activity, steroid use

Anti-Ro antibodies in lupus portend higher disease activity, steroid use

Patients with systemic lupus erythematosus who are positive for anti-Ro60 or anti-Ro52 antibodies may face higher disease activity and more intensive treatment needs, according to data published in Rheumatology.

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August 27, 2024
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ACR advises against glucocorticoids for interstitial lung disease in systemic sclerosis

ACR advises against glucocorticoids for interstitial lung disease in systemic sclerosis

New recommendations from the American College of Rheumatology and the American College of Chest Physicians strongly advise against glucocorticoids for interstitial lung disease in systemic sclerosis.

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July 31, 2024
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Wheezing occurs less in children born during COVID-19 lockdown vs. pre-pandemic

Wheezing occurs less in children born during COVID-19 lockdown vs. pre-pandemic

Wheezing at 30 months was less frequent in children born during vs. before the COVID-19 lockdown, according to a research letter published in JAMA Network Open.

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July 29, 2024
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Glucocorticoids ‘not absolutely evil,’ but difficult to taper in giant cell arteritis

Glucocorticoids ‘not absolutely evil,’ but difficult to taper in giant cell arteritis

Glucocorticoids are an effective go-to treatment for giant cell arteritis, but discontinuing them can be difficult, according to a presenter at the 2024 AWIR annual conference.

Clinical Guidance
Lupus
Treatment Options

Pharmacotherapeutic Options

Irene Blanco, MD, MS

This section covers the individual pharmacotherapeutic options for SLE, including their appropriate uses in SLE and the efficacy and safety data supporting their use. 

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June 13, 2024
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Higher steroid dose improves lupus nephritis renal outcomes, raises mortality risk

Higher steroid dose improves lupus nephritis renal outcomes, raises mortality risk

Patients with lupus nephritis who receive higher initial doses of glucocorticoids demonstrate improved renal outcomes, albeit with increased serious infection and mortality risks, according to data published in Arthritis & Rheumatology.

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June 06, 2024
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VIDEO: Possible game-changer for people with congenital adrenal hyperplasia

VIDEO: Possible game-changer for people with congenital adrenal hyperplasia

BOSTON —In this video exclusive, Richard J. Auchus, MD, PhD, describes a possible new treatment paradigm for congenital adrenal hyperplasia with crinecerfont, an investigational drug granted a breakthrough designation in December.

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June 02, 2024
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Oral therapy cuts androstenedione levels for children with congenital adrenal hyperplasia

Oral therapy cuts androstenedione levels for children with congenital adrenal hyperplasia

BOSTON — Crinecerfont lowered androstenedione levels and allowed for lower glucocorticoid doses for children with classic congenital adrenal hyperplasia, according to findings from the CAHtalyst Pediatric phase 3 trial.

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June 01, 2024
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Oral nonsteroidal treatment ‘new paradigm’ for adults with congenital adrenal hyperplasia

Oral nonsteroidal treatment ‘new paradigm’ for adults with congenital adrenal hyperplasia

BOSTON — Adults with congenital adrenal hyperplasia receiving an oral nonsteroidal treatment saw a marked reduction in daily glucocorticoid dose at 24 weeks with maintenance of androgen control compared with placebo, researchers reported.

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