Genome-Wide Association Study

The B-glucocerebrosidase protein was a novel risk factor for Parkinson’s disease in African or African admixed populations and may assist in targeted treatments for these populations, according to a study published in The Lancet Neurology.

Findings of a genome-wide association study suggested a heritable component of treatment-resistant schizophrenia, according to results published in JAMA Psychiatry.

Increasing sample sizes in genetic studies, regardless of the depth of phenotyping, may help better estimate risk for depression, according to results of a case-control polygenic risk score analysis published in JAMA Psychiatry.

A 10-item screen for alcohol use disorder appeared valuable for clinical and genetic studies related to the disorder, according to results of a genome-wide association study published in American Journal of Psychiatry.

A polygenic risk score can predict adult short stature among children with accuracy similar to the use of midparental height, according to data published in The Journal of Clinical Endocrinology & Metabolism.

Genetic risk factors for polycystic ovary syndrome can act independently of ovarian function, causing cardiometabolic dysfunction and hyperandrogenism through biological pathways common to both men and women, according to a speaker.

Neuroendocrine, reproductive and metabolic dysfunctions associated with polycystic ovary syndrome are transmitted in mice exposed prenatally to anti-Müllerian hormone for at least three generations, new data show.

Cannabis use disorder appeared to have a genetic association with multiple adverse psychiatric outcomes, according to results of a genome-wide association study meta-analysis published in The Lancet Psychiatry.

The etiology of type 1 diabetes continues to be debated, although experts agree it is likely a mix of genetic and environmental causes. Today, more than 50 regions of the human genome are implicated in type 1 diabetes.

Researchers have identified two distinct subtypes of polycystic ovary syndrome associated with novel gene regions, a discovery that could improve disease diagnosis and potentially provide new pathways for drug targets.