Genetic Background

QUEBEC CITY — In this video from the American Orthopaedic Foot & Ankle Society Annual Meeting, Sara E. Buckley, DO, spoke on the genetic and epigenetic factors that influence progression to end-stage ankle osteoarthritis.

Data from a Mendelian randomization analysis indicated a causal association between type 1 diabetes and hypothyroidism, leading researchers to recommend that people with type 1 diabetes undergo regular thyroid function tests.

Environmental factors play a greater role in the genesis of psychotic experiences than genetic factors among adolescents, according to a study published in JAMA Psychiatry.

Genetic risk and poorer diet quality each independently increase the risk for developing type 2 diabetes, according to study data.

Likelihood of inheritance for hypomania, which may lead to bipolar disorder or other mental illnesses, is greater in male twins than in female twins, according to a Swedish cohort study published in JAMA Psychiatry.

In this video, Lori Muffly, MD, MS, discussed an abstract on the impact of genetic ancestry on the biology and disease outcomes of childhood acute lymphoblastic leukemia that was presented at the Society of Hematologic Oncology Annual Meeting.

Fetal and infant environments do not cause type 2 diabetes or obesity. Instead, these environments make type 2 diabetes and obesity much more likely because they change the sensitivity of the individual to the obesogenic and metabolic milieu after birth.

People with a rare genetic coding variant that occurs in approximately 1 in 3,000 people had lower BMI and 54% lower odds for obesity compared with those who were not heterozygous carriers, data published in Science show.

Genetic variation, as observed using polygenic and genome-wide risk scores, may contribute to the development of atrial fibrillation in the absence of traditional CV risk factors, researchers reported.