Gene Expression

PHILADELPHIA — Researchers have identified “dozens” of new causal genes and pathways responsible for disease activity in patients with gout, according to a presenter at ACR Convergence 2022.

Higher blood neutrophil count and neutrophil-to-lymphocyte ratio predict more severe disease and increased mortality in patients with systemic sclerosis, according to data published in Arthritis Care and Research.

BOSTON — Pruritus and atopic dermatitis-related gene expression were altered after treatment with difelikefalin, according to a study presented at the American Academy of Dermatology Annual Meeting.

A single, intravenous infusion of GNT0003, an adeno-associated virus vector serotype 8, restored gene expression among patients with Crigler Najjar syndrome, according to a late breaker presentation at the International Liver Congress.

by Brook Brouha, MD, PhD