Gefitinib
Lung Cancer: Assessment and Treatment
Chemotherapy after first-line EGFR TKI fails to extend survival in advanced NSCLC
Adjuvant gefitinib extends DFS, not OS vs. chemotherapy in NSCLC subset
Osimertinib, gefitinib combination tolerated in EGFR-mutated NSCLC
Adding gefitinib to chemotherapy improves PFS in EGFR-mutant lung cancer
Gefitinib administered concurrently with carboplatin plus pemetrexed improved PFS compared with gefitinib alone among patients with untreated advanced non-small cell lung cancer with EGFR mutations, according to results of the randomized phase 3 NEJ009 trial published in Journal of Clinical Oncology.
Osimertinib improves OS in untreated, advanced NSCLC
First-line osimertinib improved OS compared with standard-of-care epidermal growth factor receptor tyrosine kinase inhibitors among patients with previously untreated advanced EGFR-mutated non-small cell lung cancer, according to results from the randomized phase 3 FLAURA trial presented at European Society for Medical Oncology Asia Congress and simultaneously published in The New England Journal of Medicine.