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Fred Hutchinson

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December 17, 2018
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B-cell maturation antigen-targeted CAR T-cell therapy potent in advanced myeloma

B-cell maturation antigen-targeted CAR T-cell therapy potent in advanced myeloma

SAN DIEGO — B-cell maturation antigen chimeric antigen receptor T cells that harbor a fully human single-chain variable fragment with a defined composition of CD4-positive and CD8-positive T cells appeared potent among patients with heavily pretreated, high-risk multiple myeloma, according to study results presented at ASH Annual Meeting and Exposition.

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December 10, 2018
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Risk adjustment ‘negates benefit’ of stem cell transplant for acute myeloid leukemia

Risk adjustment ‘negates benefit’ of  stem cell transplant for acute myeloid leukemia

SAN DIEGO — The addition of a transplant-specific comorbidity score to risk stratification appeared to negate the survival benefit of hematopoietic stem cell transplantation among older patients with acute myeloid leukemia, according to results of a prospective, multicenter, longitudinal study presented at ASH Annual Meeting and Exposition.

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December 03, 2018
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Novel risk stratification model outperforms standard prediction tools for myelodysplastic syndrome

Novel risk stratification model outperforms standard prediction tools for myelodysplastic syndrome

SAN DIEGO — A personalized risk prediction model developed using machine learning showed utility as a predictive and prognostic tool among patients with myelodysplastic syndrome, according to findings presented at ASH Annual Meeting and Exposition.

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December 02, 2018
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Progressive disease after anti-CD19 CAR T-cell therapy predicts poor lymphoma survival

SAN DIEGO — Patients with large B-cell lymphoma who experienced progressive disease following anti-CD19 chimeric antigen receptor T-cell therapy had poor long-term outcomes, according to results presented at ASH Annual Meeting and Exposition.

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December 01, 2018
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Consolidative transplant after CAR T-cell therapy may benefit certain patients with acute lymphoblastic leukemia

SAN DIEGO — Consolidative hematopoietic stem cell transplant after CD19-directed chimeric antigen receptor T-cell therapy prolonged leukemia-free survival for certain pediatric and young adult patients with relapsed or refractory CD19-positive acute lymphoblastic leukemia, according to results of the PLAT-02 trial presented at ASH Annual Meeting and Exposition.

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July 23, 2018
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Small molecule inhibitor appears effective, safe for advanced head and neck cancer

Small molecule inhibitor appears effective, safe for advanced head and neck cancer

An experimental therapy demonstrated promising efficacy when evaluated in a small cohort of patients with advanced head and neck squamous cell carcinoma, according to results of an open-label dose escalation study.

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June 08, 2018
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GVHD management improves, but questions remain about risk stratification, prophylaxis

GVHD management improves, but questions remain about risk stratification, prophylaxis

The FDA approval of ibrutinib for adults with chronic graft-versus-host disease may herald a practice-changing breakthrough in the management of this posttransplant complication.

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June 01, 2018
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Colorectal cancer treatment costs in US double those for Canada

CHICAGO — Colorectal cancer treatment for patients who lived in western Washington State cost more than twice as much as treatment for individuals with the same malignancy who lived in a demographically similar region in Canada, according to study results presented at ASCO Annual Meeting.

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April 14, 2018
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American Association for Cancer Research names academy fellows

The American Association for Cancer Research announced the newly elected fellows of the AACR Academy.

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February 22, 2018
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Ruxolitinib therapy appears safe prior to allogeneic HSCT for myelofibrosis

Ruxolitinib therapy appears safe prior to allogeneic HSCT for myelofibrosis

SALT LAKE CITY — Ruxolitinib treatment prior to allogeneic hematopoietic stem cell transplant appeared safe and aided in the prevention of cytokine release syndrome among patients with myelofibrosis, according to results of a phase 2 prospective study presented at the BMT Tandem Meetings.

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