Forced Expiratory Volume
Baseline factors impact odds for clinical remission with dupilumab in asthma
SAN DIEGO — Researchers found increased odds for clinical remission on dupilumab with high blood eosinophil and fractional exhaled nitric oxide levels in a moderate to severe asthma cohort, according to a poster presented here.
Individuals with impaired FEV1/FVC trajectories often experience wheeze before middle age
Around 20% to 25% of individuals with rapidly declining FEV1/FVC trajectories experienced wheezing and usual phlegm/bronchitis as adolescents/young adults, according to results published in The Lancet Respiratory Medicine.
Six-month asthma control score on mepolizumab predicts remission in eosinophilic asthma
Of four treatment response measures recorded at 6 months of mepolizumab treatment, an Asthma Control Questionnaire score was deemed “best predictor” of 12-month remission in patients with severe eosinophilic asthma, according to study data.
Patients with COPD, preserved ratio impaired spirometry have faster frailty progression
Frailty progression occurred at a faster rate among patients with COPD and preserved ratio impaired spirometry vs. those with normal spirometry, according to results published in CHEST.
Children’s lung function improved with classroom, bedroom air purification
In a set of healthy school-aged children, several lung function measures, including FEV1 and FVC, improved with classroom plus bedroom air purification, according to results published in JAMA Pediatrics.
Exacerbation, hospitalization rates smaller with use vs. no use of metformin in COPD
BOSTON — Among adults with COPD, the odds for exacerbations and hospitalizations were elevated in patients who did not use vs. did use the diabetes medication metformin, according to an abstract presented at the CHEST Annual Meeting.
Cystic fibrosis triple therapy outcomes improve regardless of prior modulators
BOSTON — Having vs. not having past cystic fibrosis transmembrane conductance regulator modulator exposure did not change positive outcomes seen with elexacaftor/tezacaftor/ivacaftor, according to data presented at the CHEST Annual Meeting.
Lung function ‘stable’ 3 years after hematopoietic cell transplant in sickle cell disease
Patients with sickle cell disease who had non-myeloablative hematopoietic cell transplants had similar or better lung function 3 years later, according to results published in Annals of the American Thoracic Society.
Early childhood exposure to more green spaces linked to improved lung function
Among school-age children, residence near more green spaces in early childhood positively impacted lung function, according to results published in Environment International.
AI model correctly predicts FVC, FEV1 from chest X-rays
With just chest X-rays, an AI model estimated FVC and FEV1 and had “excellent agreement” when compared with spirometry results, according to results published in The Lancet Digital Health.