Fistula
‘Unexpectedly high’ placebo response derails darvadstrocel for Crohn’s perianal fistulas
WASHINGTON — Darvadstrocel demonstrated “no statistically significant or clinically meaningful” benefit vs. placebo for complex perianal fistulas and Crohn’s disease, according to ADMIRE-CD II trial data presented at Digestive Disease Week.
VIDEO: Multimodal care, ‘aggressive’ medical treatment a must for perianal Crohn’s disease
In this Healio video exclusive, Miguel Regueiro, MD, shares highlights from his presentation at the GUILD Conference, where he discussed the importance of early, multimodal intervention in perianal fistulizing Crohn’s disease.
‘Perianal fistulas are preventable’ in pediatric Crohn’s with early anti-TNF therapy
LAS VEGAS — Early treatment with tumor necrosis antagonist was linked to 79% reduced odds of patients with pediatric Crohn’s disease developing perianal fistulizing complications, noted a presenter at the Crohn’s & Colitis Congress.
Risk score used during access surveillance may predict stenosis
Use of a risk score while monitoring the patency of a hemodialysis vascular access may help predict the development of stenosis and provide an objective measure for risk stratification, researchers concluded in a recently published study.
Hyperbaric oxygen therapy ‘safe and potentially effective’ for fistulizing Crohn’s
DENVER — Hyperbaric oxygen therapy yielded a clinical response rate of 87% among patients with fistulizing Crohn’s disease with few adverse events, according to systematic review data presented at the Crohn’s and Colitis Congress.
Updated Crohn’s fistula guidance broadens options, physicians retain ‘ultimate judgement’
The American Society of Colon and Rectal Surgeons has published clinical practice guidelines for the management of patients with cryptoglandular fistulas, rectovaginal fistulas and anorectal fistulas in the presence of Crohn’s disease.
Anti-TNF, surgical closure induces long-term healing in Crohn’s fistulas
Short-term anti-tumor necrosis factor treatment combined with surgical closure induced long-term MRI healing in patients with Crohn’s perianal fistulas more frequently than anti-TNF therapy alone, according to research.
Expert advises: ‘We must treat first’ with Crohn’s perianal fistula complications
Successful management of Crohn’s perianal fistulas relies on adequate abscess drainage and controlled healing, according to a presenter at the GUILD conference 2022.
Anti-TNF with surgery yields favorable outcomes in Crohn’s perianal fistula
Anti-tumor necrosis factor induction paired with surgical closure correlated with better long-term outcomes and decreased recurrence in patients with Crohn’s perianal fistulas, according to presented research.
Early anti-TNF induction may link to long-term fistula healing in Crohns disease
Early infliximab therapy initiation following surgery may result in long-term fistula healing among patients with perianal fistulizing Crohn’s disease, according to research published in BMC Gastroenterology.