Fibrosis

ORLANDO, Fla. — Malignancies and lung involvement are the two key manifestations of dermatomyositis that require vigilance, according to a presenter at the 2024 Rheumatology Nurses Society annual conference.

Matrix metalloproteinase 2 may be associated with the progression of chronic kidney disease, especially in patients with low inflammation or with proteinuria, data show.

PARK CITY, Utah — In this Healio Video Perspective from Clinical Trials at the Summit, Patricio Schlottmann, MD, discusses dual inhibition of the Ang-2 and VEGF pathways.

In a Healio video exclusive, Anu Osinusi, MD, MPH, reported long-term bulevirtide monotherapy 2 mg and 10 mg remained safe and effective for chronic hepatitis D virus with improved biochemical, fibrosis and virologic markers at 144 weeks.

Treatment with efruxifermin resulted in significant improvement in fibrosis at week 24 in patients with metabolic dysfunction-associated steatohepatitis, which was “sustained and expanded through week 96,” according to late-breaking data.

Survodutide was superior to placebo and significantly improved markers of metabolic dysfunction-associated steatohepatitis without worsening of fibrosis, according to data presented at EASL Congress.

Food insecurity was associated with lower odds of metabolic dysfunction-associated steatotic liver disease among patients with HIV, although the presence of diabetes increased the odds of fibrosis in this population, according to data.

Vibration-controlled transient elastography-based Agile scores accurately predicted liver-related events in patients with metabolic dysfunction-associated steatotic liver disease and “may be suitable alternatives” to routine liver biopsy.

Efruxifermin with a glucagon-like peptide-1 receptor agonist was well-tolerated and reduced hepatic fat fraction and noninvasive markers of fibrosis among patients with metabolic dysfunction-associated steatohepatitis and type 2 diabetes.

The organization of cells in scar tissue around pancreatic tumors may help predict survival, according to researchers at Stanford Medicine.