Fecal Microbiota Transplantation

Recurrence of hepatic encephalopathy was lower among patients with cirrhosis and hepatic encephalopathy who received oral capsule or enema fecal microbiota transplant vs. placebo, according to research from EASL Congress.

WASHINGTON — In a Healio video exclusive, Paul Feuerstadt, MD, FACG, AGAF, discusses real-world results for Rebyota as a treatment of recurrent Clostridioides difficile infection, which were presented at Digestive Disease Week.

In a Healio exclusive, Ari Grinspan, MD, predicted that while microbiota therapeutics are currently “not ready for prime time,” they will eventually become part of the treatment strategy for patients with inflammatory bowel disease.

Pretreatment with budesonide did not significantly influence engraftment among patients with ulcerative colitis who underwent fecal microbiota transplantation, with researchers reporting that clinical response appeared to be donor-dependent.

Although effective in select patients, the AGA advised against fecal microbiota-based therapies to prevent recurrent Clostridioides difficile infection in severely immunocompromised adults or to treat other gastrointestinal conditions.

From a shift in nomenclature for steatotic liver disease to how a boom in live biotherapeutics will revamp treatment for Clostridioides difficile infection, Healio was at the forefront of gastroenterology and hepatology coverage in 2023.

Clostridioides difficile infection presents a unique treatment paradox for clinicians: Antibiotics are often both its cause and its cure.

Each December, the International Foundation for Gastrointestinal Disorders celebrates Constipation Awareness Month, in the hopes of boosting public awareness about constipation and providing support to those who suffer from the condition.

Despite the availability of fecal microbiota transplantation and FDA-approved live biotherapeutics for recurrent Clostridioides difficile infection, some patients have turned to risky “homebrew” methods to correct their gut microbiome.