Familial Hypercholesterolemia
Most adults with FH do not reach guideline-recommended cholesterol targets
About 75% of adults with heterozygous familial hypercholesterolemia do not meet guideline-recommended LDL treatment targets, whereas women with familial hypercholesterolemia are less likely than men to be appropriately treated, data show.
General practitioner-led HeFH screening, care may be cost-effective vs. standard care
An Australian general practitioner-led screening and care program for heterozygous familial hypercholesterolemia was projected to be cost-effective with significant return on investment vs. standard care, researchers reported.
Alirocumab improves coronary plaque burden in asymptomatic patients with FH
PCSK9 inhibition with alirocumab, on top of high-intensity statin therapy, resulted in significant coronary plaque regression among patients with familial hypercholesterolemia and no clinical atherosclerotic CVD, researchers reported.
REFERCHOL
Assessing odds for subclinical ASCVD by midlife based on maternal inheritance of FH.
FDA extends approval of evinacumab for HoFH to children aged 5 to 11 years
Regeneron Pharmaceuticals announced the FDA has extended approval of evinacumab-dgnb as an adjunct to other lipid-lowering therapy for the treatment of homozygous familial hypercholesterolemia in children aged 5 to 11 years.
Healthy lifestyle can cut CVD risk in patients with FH
A healthy lifestyle was associated with reduced risk for CVD among adults with familial hypercholesterolemia regardless of their familial hypercholesterolemia mutation status, researchers reported.
USPSTF: Evidence is insufficient to support lipid disorder screening in asymptomatic kids
There is not yet enough evidence to adequately assess the benefit-harm balance of screening for lipid disorders in asymptomatic children and adolescents aged 20 years or younger, according to a statement from the U.S. Preventive Services Task Force.
Maternal inheritance of FH may increase odds of subclinical coronary calcium by midlife
Researchers in France observed that maternal inheritance of familial hypercholesterolemia was associated with greater odds of having subclinical coronary atherosclerosis compared with paternal inheritance of the gene mutation.
Patients with familial hypercholesterolemia may be more vulnerable to eating disorders
A study published in the European Journal of Preventive Cardiology found that patients with familial hypercholesterolemia may have elevated risk for developing eating disorders.
Q&A: Familial hypercholesterolemia often 'hidden in plain sight'
When discussing high cholesterol with patients, physicians should consider the possibility of familial hypercholesterolemia, according to Ijeoma Isiadinso, MD, MPH, FACC, FASNC.