Exercise

Boehringer Ingelheim and Eli Lilly and Co. announced negative top-line results for its EMPERIAL-Reduced and EMPERIAL-Preserved trials, nothing that the SGLT2 inhibitor empagliflozin did not meet the primary endpoint of improvements in exercise ability according to the 6-minute walk test from baseline to 12 weeks compared with placebo in patients with chronic HF with reduced and preserved ejection fraction.

News that the FDA is investigating metformin products to determine if potentially carcinogenic agents are present was one of the week’s top stories in endocrinology.

LOS ANGELES — Exercise provides important and varied benefits for individuals with cardiometabolic disorders regardless of experience level, and certain exercise types may yield better outcomes for those with certain conditions, according to a speaker at the World Congress on Insulin Resistance, Diabetes and Cardiovascular Disease.

PHILADELPHIA — Compared with moderate-intensity continuous training and controls who received advice based on national physical fitness standards in Norway, 5 years of supervised high-intensity interval training was associated with improved rates of all-cause mortality in older adults.

PHILADELPHIA — Adults with type 2 diabetes and obesity without CVD experienced dramatic metabolic improvements after a 12-week, low-calorie diet intervention but saw no change in diastolic function, which was only observed with an aerobic exercise intervention, according to data presented at the American Heart Association Scientific Sessions.

Most adolescents worldwide — including more girls than boys — fail to meet WHO physical activity guidelines, putting their health at risk, according to a study published in Lancet Child and Adolescent Health.

A moderate-intensity exercise regimen appeared to improve skeletal muscle microvasculature among patients with sickle cell disease, according to results of a randomized trial published in Blood.

PHILADELPHIA — Udenafil in adolescents after Fontan surgery did not significantly improve oxygen consumption at peak exercise, although it did significantly improve exercise performance at the ventilatory anaerobic threshold, according to data from the FUEL trial presented at the American Heart Association Scientific Sessions.

Among people with a genetic predisposition for depression, 4 additional hours of physical activity may reduce the odds of incident depression by 17%, according to results of a biobank cohort study published in Depression & Anxiety.

Introducing the exercise component of a behavioral weight-loss program 6 months after beginning dietary changes did not make a substantial impact on long-term weight loss compared with incorporating exercise right away, according to findings published in Obesity.