Endocrine Therapy

Compared with endocrine therapy alone, CDK4/6 inhibitors plus endocrine therapy improved subsequent progression-free survival and time to subsequent chemotherapy in patients with HR-positive, HER2-negative advanced breast cancer, according to research presented at ASCO 2021.

Healio spoke with Debu Tripathy, MD, about the use of biotherapies in combination with endocrine therapy in breast cancer.

In this video, Kelly K. Hunt, MD, FACS, FSSO, professor and chair of the department of breast surgical oncology at University of Texas MD Anderson Cancer Center, discussed presentations in neoadjuvant endocrine therapy at the 38th Miami Breast Cancer Conference.

Evaluating recurrence score and Ki67 better defined subsequent treatment for women with hormone receptor-positive, HER2-negative early breast cancer, according to study results presented at the virtual San Antonio Breast Cancer Symposium.

The addition of 1 year of palbociclib to endocrine therapy failed to improve invasive DFS among women with hormone receptor-positive, HER2-negative high-risk breast cancer, according to results of the phase 3 PENELOPE-B trial.

Susan G. Komen selected two breast cancer researchers to receive Brinker Awards, the nonprofit organization’s highest scientific honor.

The addition of abemaciclib to endocrine therapy significantly extended invasive DFS.

Increased time to surgery for ductal carcinoma in situ appeared associated with a small increase in pathologic upstaging but did not impact OS, according to a retrospective study published in Journal of the American College of Surgeons.

Adjuvant chemotherapy plus endocrine therapy appeared to produce early — but not sustained — cognitive impairment compared with endocrine therapy alone for women with early breast cancer, according to patient-reported data from the TAILORx trial published in Journal of Clinical Oncology.

Although ESR1 mutations are rare at the time of primary breast cancer diagnosis, they predict eventual resistance to standard adjuvant hormone therapy, according to study results presented at the virtual American Association for Cancer Research Annual Meeting.