Diuretic

According to published data, diuretic use, dosing and monitoring varies in United States hemodialysis practice.

Dapagliflozin for worsening HF was both safe and efficacious regardless of diuretic use or dose, according to findings from the DAPA-HF trial published in Circulation.

A study conducted in France found adverse drug reactions were common in patients with chronic kidney disease, most notably due antithrombotic agents, but researchers suggested many of these reactions may be preventable.

Calcium channel blockers that are often prescribed to older adults with hypertension can cause peripheral edema, which many physicians misinterpret as a new medical condition and subsequently prescribe diuretics, according to research published in JAMA Internal Medicine.

Safety and effectiveness of common antihypertensive treatments.

The week’s top story in cardiology was about a study that found thiazide or thiazide-like diuretics were superior to angiotensin-converting enzyme inhibitors for hypertension, while drug classes used as monotherapy were comparable.

Drug classes used as monotherapy for hypertension were shown to be comparable, although thiazide or thiazide-like diuretics were superior to ACE inhibitors, according to results from the LEGEND-HTN study published in The Lancet.

Acute and chronic HF are associated with sodium retention leading to volume overload and edema.