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Dipeptidyl-Peptidase IV Inhibitor

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March 05, 2025
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GLP-1s ‘modestly lower’ the risk for depression in adults with diabetes

The use of GLP-1 receptor agonists corresponded with a lower risk for depression among older adults with type 2 diabetes compared with dipeptidyl peptidase 4 inhibitors, results of a target trial emulation study suggested.

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January 14, 2025
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GLP-1 receptor agonists tied to similar thyroid cancer risk as DPP-IV inhibitors

Adults with type 2 diabetes using a GLP-1 receptor agonist have a similar risk for developing thyroid cancer as those using a DPP-IV inhibitor, according to findings published in Thyroid.

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August 12, 2024
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GLP-1 use tied to lower risk for hyperkalemia than DPP-IV therapy in type 2 diabetes

Adults with type 2 diabetes using a GLP-1 receptor agonist are less likely to develop hyperkalemia than those using a DPP-IV inhibitor, according to a study published in JAMA Internal Medicine.

Clinical Guidance
Type 2 Diabetes
Pharmacologic Intervention

Dipeptidyl Peptidase-4

Steven V. Edelman, MD

Free clinical reference tool that includes treatment options; diagnosis information; guidelines; and more.

Clinical Guidance
Type 2 Diabetes
Pharmacologic Intervention

Oral Agents

Steven V. Edelman, MD

Free clinical reference tool that includes treatment options; diagnosis information; guidelines; and more.

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July 29, 2024
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DPP-IV, SGLT2 and GLP-1 drugs do not increase risk for diabetic macular edema

Use of a DPP-IV inhibitor, SGLT2 inhibitor or GLP-1 receptor agonist does not increase risk for diabetic macular edema among adults with type 2 diabetes and diabetic retinopathy, according to study data.

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May 03, 2024
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GLP-1 receptor agonist tied to similar thyroid cancer risk as DPP-IV, SGLT2 inhibitors

Adults who initiate a GLP-1 receptor agonist have a similar risk for developing thyroid cancer as those prescribed a DPP-IV inhibitor or an SGLT2 inhibitor, according to study findings published in The BMJ.

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April 22, 2024
3 min read
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Diabetes drugs helping to drive rise in US medication expenditures

Annual expenditures for diabetes medications more than tripled in the U.S. from 2011 to 2020, and the increase played a role in an overall rise in money spent on prescription drugs, according to study findings.

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September 28, 2023
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For older adults with diabetes, CV risk lower with SGLT2 or GLP-1 vs. DPP-IV therapy

Older adults with type 2 diabetes are less likely to have a cardiovascular event if they are initially prescribed an SGLT2 inhibitor or GLP-1 receptor agonist instead of a DPP-IV inhibitor, according to findings published in Diabetes Care.

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August 17, 2023
4 min read
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SGLT2 inhibitors preferred for adults with type 2 diabetes and heart failure

HOUSTON — SGLT2 inhibitors should be the first choice of therapy for adults with type 2 diabetes and heart failure, according to two speakers at the Association of Diabetes Care and Education Specialists annual meeting.

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