Cyclophosphamide
Rituximab superior to cyclophosphamide in GPA remission induction
In patients with granulomatosis with polyangiitis, those who start induction therapy with rituximab are more likely to achieve remission compared with those who begin cyclophosphamide, according to data published in JAMA Network Open.
Novel regimen significantly lowers GVHD risk after reduced-intensity allogeneic HSCT
NEW ORLEANS — A regimen containing post-transplant cyclophosphamide significantly lowered graft-versus-host disease risk among adults who underwent reduced-intensity allogeneic hematopoietic stem cell transplant, study results showed.
Cyclophosphamide treatment for systemic sclerosis linked to lower ovarian reserve in women
NASHVILLE, Tenn. — In women with systemic sclerosis, cyclophosphamide therapy negatively correlated with ovarian reserve, according to a presenter at the CHEST Annual Meeting.
Cyclophosphamide plus high-dose glucocorticoids did not confer survival benefit in IPF
In patients with acute exacerbation of idiopathic pulmonary fibrosis, adding IV cyclophosphamide to high-dose glucocorticoids increased mortality at 3 months, researchers reported at the European Respiratory Society International Congress.
High-dose lymphodepletion regimen effective but more toxic for patients receiving TILs
A lower dose of cyclophosphamide during preconditioning prior to tumor-infiltrating lymphocyte infusion appeared comparably effective but less toxic than a higher dose, according to results published in Journal for ImmunoTherapy of Cancer.
Post-transplant cyclophosphamide increases risk for early cardiac events
Post-transplant cyclophosphamide reduced incidence of graft-versus-host disease but led to higher incidence of early cardiac events after allogeneic hematopoietic stem cell transplantation, according to study results.
Evidence inconclusive for immunosuppressing drugs’ influence on men’s sexual health
A systematic review of 161 studies showed a lack of conclusive evidence on the influence and safety of immunosuppressive drugs on male sexual health, according to a study published in Human Reproduction Update.
Toxicity minimal with novel transplantation approach for transfusion-dependent thalassemia
ORLANDO — Nonmyeloablative conditioning in combination with post-transplant cyclophosphamide and thiotepa appeared feasible for patients with severe transfusion-dependent thalassemia undergoing bone marrow transplantation, according to results of a phase 1 study presented at TCT | Transplantation & Cellular Therapy Meetings.
Acute GVHD less severe after haploidentical transplant with post-cyclophosphamide prophylaxis
ORLANDO — Acute graft-versus-host disease tended to be less severe among patients who underwent haploidentical transplantation with post-cyclophosphamide prophylaxis than those who underwent 8/8 HLA-matched unrelated donor stem cell transplant with standard prophylaxis, according to study results presented at TCT | Transplantation & Cellular Therapy Meetings.
Repeat rituximab superior to azathioprine for preventing relapse in ANCA-associated vasculitis
ATLANTA — Treatment with repeat doses of rituximab is superior to daily azathioprine for preventing relapse among patients with ANCA-associated vasculitis with a history of relapse, according to data presented at the 2019 ACR/ARP Annual Meeting.