Crohn's Disease

The FDA has denied a biologics license application from Alvotech for its biosimilar to ustekinumab, citing “certain deficiencies” at the company’s facility in Reykjavik, Iceland, according to the manufacturer.

Topline findings from the phase 3 VIVID-1 trial showed Eli Lilly’s mirikizumab, an interleukin-23p19 antagonist, demonstrated clinical remission and endoscopic response through 52 weeks in adults with moderate to severe Crohn’s disease.

Patients with axial spondyloarthritis and other related inflammatory diseases demonstrate common microbiome dysfunction characteristics, according to data published in Arthritis & Rheumatology.

With inflammatory bowel disease on the rise in the South Asian community, patients face barriers to diagnosis and treatment, lack of insurance, stigmatization and low cultural competence from specialists — if a specialist can be found at all.

Fatigue is a “burdensome and highly prevalent” symptom of patients with active and inactive inflammatory bowel disease and is strongly associated with depression, researchers reported in BMC Gastroenterology.

Psychological therapies provided short-term improvements in anxiety, depression, stress and quality of life in people with quiescent inflammatory bowel disease but did not improve disease activity or prevent relapse, according to analysis.

Concomitant use of 5-aminosalicylic acid did not affect the overall safety and efficacy of IV or subcutaneous vedolizumab in patients with inflammatory bowel disease, according to a post hoc analysis in the Journal of Crohn’s and Colitis.

Although inflammatory bowel disease is a widespread, chronic condition in the United States, it is less commonly diagnosed in Black, Asian and Hispanic Americans, according to data reported in Gastroenterology.

Patients with inflammatory bowel disease infected with SARS-CoV-2 during the first and second waves of the pandemic experienced different symptoms and outcomes, consistent with those of the general population in Italy, researchers reported.

When it comes to dietary management of inflammatory bowel disease, it is important to make the distinction between diet and nutrition.