Cortisol
Adrenal tumors observed in 1.4% of large screening cohort in China
A little more than 1% of adults in a general screening population who underwent a CT scan had adrenal tumors, and more than two-thirds of all tumors were nonfunctioning, according to a study published in the Annals of Internal Medicine.
LOGICS: Levoketoconazole improves cortisol control in endogenous Cushing’s syndrome
SAN DIEGO — Compared with placebo, levoketoconazole improved cortisol control and serum cholesterol levels for adults with endogenous Cushing’s syndrome, according to results from the LOGICS study presented here.
VIDEO: Biotin supplementation interferes with standard hormone, other assays
SAN DIEGO — In this video exclusive, Saleh Aldasouqi, MD, FACE, ECNU, discusses the false high or false low results of certain hormone tests for people who take high doses of biotin in beauty and energy supplements, for example.
Immunohistochemistry-guided sequencing finds mutations in most cortisol-producing adenomas
The use of an immunohistochemistry‒guided targeted amplicon sequencing approach using formalin-fixed, paraffin-embedded tissue detected somatic mutations in more than 70% of cortisol-producing adenomas, according to study data.
Osilodrostat normalizes urinary free cortisol in most adults with Cushing’s disease
More than three-quarters of adults with Cushing’s disease assigned osilodrostat had a normalized mean urinary free cortisol level at 12 weeks and maintained a normal level at 36 weeks, according to data from the LINC 4 phase 3 trial.
Inhaled corticosteroid asthma treatment linked to adrenal suppression
Even low-dose treatment courses of inhaled corticosteroids for asthma can lead to adrenal suppression including fatigue, headache, abdominal pain, vomiting and psychiatric symptoms, according to a study published in Nature Medicine.
Mild autonomous cortisol secretion in benign adrenal tumors increases cardiometabolic risk
Mild autonomous cortisol secretion is prevalent in nearly half of adults with benign adrenal tumors and can increase the risk for hypertension and type 2 diabetes, according to study data published in the Annals of Internal Medicine.
Free cortisol evaluation ‘useful’ after abnormal dexamethasone test
An assessment of free cortisol after a dexamethasone suppression test could add value to the diagnostic workup of hypercortisolism, which can be plagued by false-positive results, according to data from a cross-sectional study.
Glucocorticoid sensitivity may increase risk for stress-related diseases
Healthy adults with the highest sensitivity to glucocorticoids have a proteomic profile suggesting a greater capability for responding to stressful stimuli compared with those with lowest sensitivity, according to study data.
COVID-19 associated with impaired adrenocortical response in hospitalized patients
Most patients hospitalized with COVID-19 at a hospital in Saudia Arabia in May 2020 had an impaired hypothalamic-pituitary-adrenal response, with plasma cortisol at central adrenal insufficiency levels, according to study data.