Corticosteroid

Triple therapy, compared with dual therapy, was associated with fewer asthma exacerbations and modest improvements in asthma control in children and adults with moderate to severe asthma, according to a new meta-analysis.

Long-term corticosteroid use is associated with significant increases in perioperative adverse outcomes for patients undergoing elective posterior lumbar surgery, according to published results.

The incidence of steroid response with prednisolone acetate 1% was low after phacoemulsification in eyes with and without glaucoma, according to a study published in the Journal of Glaucoma.

Oral corticosteroid bursts were associated with a 1.4- to 2.2-fold increased risk for gastrointestinal bleeding, sepsis and pneumonia among children within the first month after use, according to study results published in JAMA Pediatrics.

Despite an ever-growing array of therapeutic options, patients with antineutrophil cytoplasmic antibody-associated vasculitis often fail to achieve remission, according to a speaker at the ACR State-of-the-Art Clinical Symposium.

Patients hospitalized with COVID-19 had shorter times to clinical improvement when treated with remdesivir, but the drug had no significant effect in a time-to-death analysis, even when given with corticosteroids, according to researchers.

Rheumatoid arthritis is independently linked to worse prognosis following myocardial infarction, with disease duration and corticosteroid use predicting mortality after myocardial infarction, according to data published in Rheumatology.

Patients with oral corticosteroid-dependent asthma treated with benralizumab achieved OCS elimination or reduction in those in whom adrenal insufficiency was detected, regardless of baseline eosinophil count, in the PONENTE trial.

Researchers who compared kidney transplant recipients randomized to withdrawal or continue corticosteroids 7 days after the procedure found no difference in allograft survival at 15 years.

Glucocorticoids, even at a low dose, may increase the risk for COVID-19, while immunomodulatory treatments appear safe for patients with inflammatory arthritis, according to data published in Arthritis Research & Therapy.