Common Variable Immunodeficiency

Artificial intelligence can improve care for patients with primary immunodeficiencies, but human input is still necessary, Nicholas L. Rider, DO, said at Updates in Primary Immunodeficiency 2025.

Patients with primary immunodeficiencies experience an average of 9 to 15 years between the onset of their symptoms to diagnosis of their disorder and treatment that could save their lives, according to the Immune Deficiency Foundation.

Although allergists/immunologists frequently encounter ethical dilemmas in their daily clinical practice, medical ethics has not previously been a focus of research and training in their specialty, Timothy M. Buckey, MD, MBE, told Healio.

WASHINGTON — Children with primary immunodeficiencies should receive routine inactive vaccinations and other prophylactic treatment, according to a presentation at the American Academy of Allergy, Asthma & Immunology Annual Meeting.

Patients with diagnoses of various IgE deficiencies do not share equal odds for developing malignancies, according to a study published in The Journal of Allergy and Clinical Immunology: In Practice.

ANAHEIM, Calif. — A woman who could not tolerate immunoglobulin replacement therapy benefitted from C1-INH replacement therapy, according to a presentation at the American College of Allergy, Asthma & Immunology Annual Scientific Meeting.

LOUISVILLE, Ky. — Patients with noninfectious complications of common variable immunodeficiency, such as gastrointestinal disease, malignancy and rheumatoid arthritis, had increased mortality risk, according to study results.

“Communication problems” that result from defects in types of immune cells including B cells impair immune response and may play a role in common variable immunodeficiency, according to a study published in Nature Communications.