Colorectal Cancer
Top in GI: Excess weight and colorectal cancer; herbal extracts in ulcerative colitis
Individuals with a BMI of 30 kg/m² or more had an increased risk for colorectal cancer compared with individuals with normal weight, regardless of polygenic risk score, according to a study published in JAMA Network Open.
Trifluridine/tipiracil plus bevacizumab prolongs survival in refractory colorectal cancer
The addition of bevacizumab to trifluridine/tipiracil demonstrated a statistically significant and clinically meaningful improvement in OS vs. trifluridine/tipiracil alone among adults with refractory metastatic colorectal cancer.
Follow-up colonoscopy rates after positive colorectal cancer screening result are low
Many patients who received a positive stool-based screening test result for colorectal cancer did not receive a follow-up colonoscopy within 1 year, according to the results of a mixed-methods cohort study.
FDA approves Tukysa regimen for RAS wild-type, HER2-positive metastatic colorectal cancer
The FDA granted accelerated approval to tucatinib in combination with trastuzumab for adults with RAS wild-type, HER2-positive metastatic or unresectable colorectal cancer, according to a company press release.
Excess weight increased risk for colorectal cancer, independent of genetic risk
Excess weight, regardless of polygenic risk score, correlated with an increased risk for colorectal cancer, according to results from a population-based, case-control study.
Advanced colorectal neoplasia prevalence remains low 10 years after negative colonoscopy
Researchers reported low prevalence for advanced colorectal neoplasms at screening colonoscopies conducted at least 10 years after a negative index colonoscopy, especially among women younger than 75 years.
Genescopy encourages colonoscopy with noninvasive CRC screening test
Geneoscopy Inc. announced favorable results from its CRC-PREVENT trial, which assessed noninvasive, stool-based, at-home screening for colorectal cancer and advanced adenomas.
Neoadjuvant immunotherapy a potential new standard of care for localized colorectal cancer
Neoadjuvant treatment with immune checkpoint inhibitors for colorectal cancer induced clinical responses that helped delay or prevent surgical resection, results of a study in Journal of the National Comprehensive Cancer Network showed.
Analysis identifies 50 new genetic variants linked to colorectal cancer risk
Multiomic analysis has provided new insights into the genetics of colorectal cancer and how genetic variants contribute to disease risk and development.
Targeted decision aids may not impact CRC screening preference among older adults
Although decision aids helped inform older adults about potential benefits and risks associated with colorectal cancer screening, the tools did not significantly influence patient preference for screening, regardless of health.