Cognitive Impairment

Biopharmaceutical company Aptinyx reported its drug for cognitive impairment was not efficacious in a phase 2 clinical trial investigating its use in patients with Parkinson’s disease and Lewy body dementia, according to a press release.

Perceived stress was associated with both prevalent and incident cognitive function impairment in Black and white older adults, underlining the need for stress assessments among high-risk adults in primary care, according to researchers.

SAN ANTONIO — Elevated cognitive impairment appeared linked to weak asthma control among older adults, according to an abstract presented at the American Academy of Allergy, Asthma & Immunology Annual Meeting.

Early mobilization of mechanically ventilated adults lowered the risk for cognitive impairment 1 year following hospital discharge by 19%, according to a study published in The Lancet Respiratory Medicine.

Patients with e-cigarette- or vaping-associated lung injury, or EVALI, frequently showed long-term cognitive impairment, respiratory limitations and mood disorders, according to a study published in Annals of the American Thoracic Society.

Higher levels of the inflammatory marker C-reactive protein predicted lower reported cognitive function among older breast cancer survivors, according to study results published in Journal of Clinical Oncology.

History of stroke was associated with increased odds of cognitive impairment in both non-Hispanic white and Mexican American individuals, researchers reported.

Aptinyx Inc. announced it has completed enrollment in the company’s ongoing phase 2 study of NYX-458, an oral treatment for cognitive impairment associated with Parkinson’s disease and dementia with Lewy bodies.

Changes in obstructive sleep apnea status were linked with white matter integrity and cognitive performance, suggesting that timely intervention of OSA could help preserve brain health, researchers reported in JAMA Network Open.

Data from a genetics-based study show PCSK9 inhibition does not affect cognition function or dementia risk; however, statin use may be associated with some impaired cognitive performance that is outweighed by any CV benefits.