Cognitive Impairment

A phase 2 clinical trial of dalzanemdor in those with cognitive impairment associated with Huntington’s disease failed to meet its primary and secondary endpoints, causing the manufacturer to halt development of the investigational therapy.

CHICAGO — In the BRAIN-AF trial, daily rivaroxaban did not reduce the incidence of cognitive decline, stroke or transient ischemic attack, compared with placebo, among younger patients with atrial fibrillation and low stroke risk.

In a cohort of community-dwelling older adults, poor sleep quality was indicative of incident motoric cognitive risk syndrome as well as increased physical and mental disability, according to research published in Neurology.

Alterations in white matter integrity were linked to cognitive impairment, and associations were strongest in those with major depressive disorder compared with healthy controls, according to new research.

October 29 is World Stroke Day, which aims to raise awareness of the condition and how to prevent it.

Women with breast cancer who began an aerobic exercise program at the start of chemotherapy self-reported improved cognitive function and quality of life, according to results of a randomized trial.

Higher adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay, or MIND) diet reduced the risk for cognitive impairment, particularly in women, results from a cohort study published in Neurology showed.

Adults with lower cognitive scores before kidney transplantation had similar kidney function, hospital length of stay and readmission and death rates as those with higher pre-transplant scores, according to study data.

Around one-third of former professional football players perceived themselves as having chronic traumatic encephalopathy, according to results from a cross-sectional study published in JAMA Neurology.

Severe menopause symptoms, such as hot flashes and depressive mood, were associated with mild cognitive impairment for postmenopausal women, researchers reported in Menopause.