Cognitive Impairment

The FDA granted orphan drug designation to ALS001, an autologous, expanded T-cell therapy under development by Coya Therapeutics for treating ALS, according to a press release.

Statin therapy was not associated with dementia, mild cognitive impairment and/or any of its subclassifications, according to a secondary analysis of the ASPREE trial of aspirin therapy among older adults.

Approximately one-fifth of patients with MS exhibited a deterioration in cognitive status over 5 years, according to results of a cohort study conducted in the Netherlands and published in Neurology.

Study results showed an association between normal-tension glaucoma and dementia-related cognitive impairment.

Transplant recipients who were converted from tacrolimus to belatacept showed improvements in various domains of cognition, suggesting this treatment change may help reverse cognitive impairment.

Living in the most disadvantaged neighborhoodss correlated with increased degeneration in Alzheimer’s disease “signature” regions of the brain and cognitive decline, according to the results of a longitudinal study in cognitively healthy adults.

Patients with Parkinson’s disease who increased their physical activity saw positive modification of the APOE e4 allele’s impact on early cognitive decline, according to findings from a multicenter cohort study published in Neurology.

Dual sensory impairment in vision and hearing increased the rate of dementia and cognitive decline over the course of a 6-year follow-up period, according to findings from a community-based elderly cohort study published in Neurology.

Obstructive sleep apnea, or OSA, is common among older adults with cognitive impairment, and it was associated lower scores on cognition tests and poorer sleep quality, researchers reported.

A novel glycine transporter inhibitor improved cognition after 12 weeks among individuals with schizophrenia, according to results of a double-blind, randomized, placebo-controlled phase 2 study published in The Lancet Psychiatry.