Clinical Trials

DENVER — A combination therapy of ciprofloxacin and celecoxib demonstrated a favorable safety profile for those with amyotrophic lateral sclerosis, Merit Cudkowicz, MD, MSc, said in this Healio video.

Aldeyra Therapeutics has enrolled the first patient in a phase 3 clinical trial designed to allow possible resubmission of the new drug application of topical 0.25% reproxalap for dry eye disease, according to a company press release.

FORT LAUDERDALE, Fla. — In this Healio Video Perspective from the Retina World Congress, Pravin U. Dugel, MD, of Ocular Therapeutix, overviews clinical results for Axpaxli, an axitinib implant for wet age-related macular degeneration.

The FDA has granted breakthrough therapy designation to a proprietary oligonucleotide conjugate for the treatment of myotonic dystrophy type 1, according to the manufacturer.

Geographic disparities in the availability of cancer clinical trials throughout the United States have worsened over time, according to study data published in JAMA Network Open.

DENVER — Losmapimod treatment for those with facioscapulohumeral muscular dystrophy led to no serious adverse events across three clinical trials, according to a poster at the American Academy of Neurology annual meeting.

More than 20% of patients with cancer participate in some form of clinical study, and that number is considered a “floor” estimate, according to study results published in Journal of Clinical Oncology.

A Bay Area biopharmaceutical firm has announced positive results from its phase 1 clinical trial in healthy volunteers of a novel PDE4 inhibitor being developed to treat those with cognitive impairment associated with schizophrenia.

Pregnant and lactating women have historically been excluded from most clinical research, often due to perceptions of greater legal liability if a woman, her fetus or infant is harmed by an intervention.

DENVER — A phase 3 trial of ulixacaltamide for essential tremor will involve at-home patient participation and a clinical endpoint of activities of daily living, according to a speaker at the American Academy of Neurology annual meeting.